Evidence map›Paper›PMID 28711343›Full record

ReviewNeuroscience letters2019

Innexin expression in electrically coupled motor circuits.

Adriane G Otopalik, Brian Lane, David J Schulz, Eve Marder

Open access · hybridAbstract readReview
In one paragraph

Review in Neuroscience letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Defining the electrical synapse.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Adriane G OtopalikVolen Center and Biology Department, Brandeis University, Waltham, MA 02454, USA. Electronic address: aotopali@brandeis.edu.
Brian LaneDivision of Biological Sciences, University of Missouri-Columbia, Columbia, MO, 65211, USA.
David J SchulzDivision of Biological Sciences, University of Missouri-Columbia, Columbia, MO, 65211, USA.
Eve MarderVolen Center and Biology Department, Brandeis University, Waltham, MA 02454, USA.
Brandeis University · USUniversity of Missouri · US

Funding

NEUROSCIENCE: FROM CHANNELS TO BEHAVIORT32MH019929 · NIMH · BRANDEIS UNIVERSITY · PI GRIFFITH, LESLIE C · 1994 to 2023
$8.5M
Neuromodulation and Robustness of Neurons and NetworksR35NS097343 · NINDS · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 2017 to 2024
$7.8M
Variability and Compensation in Reliable Neuronal NetworksR01MH046742 · NIMH · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 1990 to 2025
$7.8M
Undergraduate and Graduate Training in Computational NeuroscienceT90DA032435 · NIDA · BRANDEIS UNIVERSITY · PI MILLER, PAUL · 2011 to 2020
$1.6M
INTRINSIC PLASTICITY IN OSCILLATORY NEURAL NETWORKSR37MH046742 · NIMH · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 1995 to 2004
$1.5M
Spatial mapping of receptor distributions on single identified neuronsF31NS092126 · NINDS · BRANDEIS UNIVERSITY · PI OTOPALIK, ADRIANE GERNDT · 2015 to 2016
$51k
NIDA NIH HHS T90 DA032435NIMH NIH HHS R01 MH046742NIMH NIH HHS R37 MH046742NIMH NIH HHS T32 MH019929NINDS NIH HHS F31 NS092126NINDS NIH HHS R35 NS097343
6 · The paper itself

Abstract

The many roles of innexins, the molecules that form gap junctions in invertebrates, have been explored in numerous species. Here, we present a summary of innexin expression and function in two small, central pattern generating circuits found in crustaceans: the stomatogastric ganglion and the cardiac ganglion. The two ganglia express multiple innexin genes, exhibit varying combinations of symmetrical and rectifying gap junctions, as well as gap junctions within and across different cell types. Past studies have revealed correlations in ion channel and innexin expression in coupled neurons, as well as intriguing functional relationships between ion channel conductances and electrical coupling. Together, these studies suggest a putative role for innexins in correlating activity between coupled neurons at the levels of gene expression and physiological activity during development and in the adult animal.

Indexed as

AnimalsConnexinsCrustaceaElectrical SynapsesGanglia, InvertebrateGap JunctionsMotor ActivityNeuronsConnexinsCardiac ganglionCentral pattern generatorsCrustaceanNeuronal homeostasisStomatogastric ganglion

Identifiers

PMID28711343
PMCPMC5767152
OpenAlexW2734708848

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.