ArticleNature communications2017
Central insulin modulates food valuation via mesolimbic pathways.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 106 citations in OpenAlex.
- Appetite Perception and Cerebral Blood Flow in Aging Adults Following a Single Bout of Exercise.Nutrients · 2026Trial
- Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study.Nature metabolism · 2023Trial
- The influence of insulin on anticipation and consummatory reward to food intake: A functional imaging study on healthy normal weight and overweight subjects employing intranasal insulin delivery.Human brain mapping · 2022Trial
- Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters.eLife · 2022Trial
- Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese.JCI insight · 2022Trial
- Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight.International journal of obesity (2005) · 2022Trial
- The effect of intranasal insulin on appetite and mood in women with and without obesity: an experimental medicine study.International journal of obesity (2005) · 2022Trial
- Bleak present, bright future: II. Combined effects of episodic future thinking and scarcity on delay discounting in adults at risk for type 2 diabetes.Journal of behavioral medicine · 2021Trial
- Associations of Brain Reactivity to Food Cues with Weight Loss, Protein Intake and Dietary Restraint during the PREVIEW Intervention.Nutrients · 2018Trial
- Unhealthy fat distribution as a sex-specific predictor of declining hippocampus insulin sensitivity.Diabetologia · 2026Article
- Blunted anticipation, but not consummation, of food rewards in depression.Cell reports. Medicine · 2026Article
- Metabolism and the Mind: Investigating the Link Between Glucose Control and Reinforcement Learning in Humans.Biological psychiatry global open science · 2026Article
- The interplay of central insulin and menstrual cycle on functional brain networks and neural food cue reactivity in women.Communications biology · 2026Article
- Daytime sleepiness and specific food cravings: The moderating role of insulin sensitivity.PloS one · 2026Article
- Metabolic regulation of synaptic plasticity in anorexia nervosa.Frontiers in synaptic neuroscience · 2026Review
- Metrics of glycemic control but not body weight influence flavor nutrient conditioning in humans.Physiology & behavior · 2025Article
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- A systematic review of in vivo brain insulin resistance biomarkers in humans.Biomarkers in neuropsychiatry · 2025Review
- A short-term, high-caloric diet has prolonged effects on brain insulin action in men.Nature metabolism · 2025Article
- Altered food liking in depression is driven by macronutrient composition.Psychological medicine · 2025Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central insulin is thought to act at the neural interface between metabolic and hedonic drives to eat. Here, using pharmacological fMRI, we show that intranasal insulin (INI) changes the value of food cues through modulation of mesolimbic pathways. Overnight fasted participants rated the palatability of food pictures and attractiveness of non-food items (control) after receiving INI or placebo. We report that INI reduces ratings of food palatability and value signals in mesolimbic regions in individuals with normal insulin sensitivity. Connectivity analyses reveal insulinergic inhibition of forward projections from the ventral tegmentum to the nucleus accumbens. Importantly, the strength of this modulation predicts decrease of palatability ratings, directly linking neural findings to behaviour. In insulin-resistant participants however, we observe reduced food values and aberrant central insulin action. These data demonstrate how central insulin modulates the cross-talk between homeostatic and non-homeostatic feeding systems, suggesting that dysfunctions of these neural interactions may promote metabolic disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.