Evidence map›Paper›PMID 28725321›Full record

ArticleJournal of clinical medicine research2017

Effect of Switching From an Anti-Diabetic Loose Dose Combination to a Fixed Dose Combination Regimen at Equivalent Dosage for 6 Months on Glycemic Control in Japanese Patients With Type 2 Diabetes: A Pilot Study.

Kazutaka Aoki, Mieko Nagakura, Masataka Taguri, Hiroshi Kamiyama, Makoto Masumura, Tadashi Furuie, Masanao Oka, Kazunari Kamiko, Shigeru Nakajima, Noriko Akema and 1 more

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In one paragraph

Article in Journal of clinical medicine research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kazutaka AokiDepartment of Internal Medicine, Kanagawa Dental University, Yokosuka, Japan.
Mieko NagakuraNagakura Clinic, Yokohama, Japan.
Masataka TaguriDepartment of Biostatistics and Epidemiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Hiroshi KamiyamaDepartment of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Makoto MasumuraMasumura Naika Clinic, Yokohama, Japan.
Tadashi FuruieFuruie Naika Clinic, Yokohama, Japan.
Masanao OkaOka Naika Clinic, Yokohama, Japan.
Kazunari KamikoDepartment of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Shigeru NakajimaNakajima Naika Clinic, Yokosuka, Japan.
Noriko AkemaIHI Yokohama Clinic, Yokohama, Japan.
Yasuo TerauchiDepartment of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with type 2 diabetes mellitus often take multiple anti-diabetic drugs for a long period. Fixed dose combination (FDC) therapy is expected to improve drug adherence for patients with diabetes. The effect of switching from a loose dose combination (LDC) regimen to an FDC regimen at equivalent dosage on glycemic control has not been evaluated fully. Therefore, we investigated the effect of switching from LDC to FDC at equivalent dosage for 6 months on glycemic control in Japanese patients with type 2 diabetes.

methodsThirty-eight Japanese patients with type 2 diabetes who were taking anti-diabetic drugs including pioglitazone + metformin, pioglitazone + alogliptin, or pioglitazone + glimepiride were enrolled. These drugs were switched to an FDC of Metact

resultsHbA1c levels at 2, 4, and 6 months were not significantly changed compared with prior to switching from an LDC to FDC regimen. Moreover, 74.2% of patients considered decreasing the number of drugs to be "very good" or "good".

conclusionHbA1c levels did not differ between patients receiving LDC and FDC therapy at equivalent dosage in this study.

Indexed as

Fixed dose combinationLoose dose combinationType 2 diabetes

Identifiers

PMID28725321
PMCPMC5505309

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.