Evidence map›Paper›PMID 28732776›Full record

ArticleBone2017

Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice.

Catherine N Withers, Drew M Brown, Innocent Byiringiro, Matthew R Allen, Keith W Condon, Jonathan Satin, Douglas A Andres

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Rad-GTPase contributes to heart rate via L-type calcium channel regulation.Journal of molecular and cellular cardiology · 2021
    Article
  3. Old Mice Have Less Transcriptional Activation But Similar Periosteal Cell Proliferation Compared to Young-Adult Mice in Response to in vivo Mechanical Loading.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Catherine N WithersDepartment of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, BBSRB, 741 S Limestone Street, Lexington, KY 40536-0509, USA. Electronic address: cka222@g.uky.edu.
Drew M BrownDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202-5120, USA. Electronic address: drebrown@iupui.edu.
Innocent ByiringiroDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202-5120, USA. Electronic address: ibyiring@umail.iu.edu.
Matthew R AllenDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202-5120, USA. Electronic address: matallen@iupui.edu.
Keith W CondonDepartment of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202-5120, USA. Electronic address: kcondon@iupui.edu.
Jonathan SatinDepartment of Physiology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536-0298, USA. Electronic address: jonathan.satin@uky.edu.
Douglas A AndresDepartment of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, BBSRB, 741 S Limestone Street, Lexington, KY 40536-0509, USA. Electronic address: dandres@email.uky.edu.
Indiana University School of MedicineUniversity of Kentucky · USIndiana University – Purdue University Indianapolis · US

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7M
Regulation of Calcium Channel Function by the Rem GTPaseR01HL072936 · NHLBI · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN, SATIN, JONATHAN · 2003 to 2013
$3.0M
Monomeric G-proteins and Cardioprotection from Heart FailureR01HL131782 · NHLBI · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN, SATIN, JONATHAN · 2017 to 2019
$1.6M
Interdisciplinary Cardiovascular Training ProgramT32HL072743 · NHLBI · UNIVERSITY OF KENTUCKY · PI RANDALL, DAVID C · 2004 to 2013
$1.3M
Monomeric G-proteins and Cardioprotection from Heart FailureR56HL131782 · NHLBI · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN, SATIN, JONATHAN · 2016 to 2016
$525k
NHLBI NIH HHS R01 HL072936NHLBI NIH HHS R01 HL131782NHLBI NIH HHS R56 HL131782NHLBI NIH HHS T32 HL072743NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

The small GTP-binding protein Rad (RRAD, Ras associated with diabetes) is the founding member of the RGK (Rad, Rem, Rem2, and Gem/Kir) family that regulates cardiac voltage-gated Ca

Indexed as

AdipogenesisAdipose TissueAnimalsBone DensityBone MarrowMiceMice, Inbred C57BLMice, KnockoutOsteogenesisras Proteinsras ProteinsRrad protein, mouseAdipogenesisBone marrow adipose tissueMatrix Gla proteinOsteoblastsOsteogenesisRas GTPase

Identifiers

PMID28732776
PMCPMC6886723
OpenAlexW2739435198

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.