Evidence map›Paper›PMID 28734273›Full record

ArticleIranian biomedical journal2018

Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-Analysis

Mahdieh Kamali, Sedigheh Hantoushzadeh, Sedigheh Borna, Hossein Neamatzadeh, Mahta Mazaheri, Mahmood Noori-Shadkam, Fatemeh Haghighi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian biomedical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 7 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 7 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  5. ASSOCIATION OF RS2435357 AND RS1800858 POLYMORPHISMS IN RET PROTO-ONCOGENE WITH HIRSCHSPRUNG DISEASE: SYSTEMATIC REVIEW AND META-ANALYSIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2019
    Pooled it
  6. Association of Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism with Recurrent Pregnancy Loss: a Meta-Analysis of 26 Case-Control Studies.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018
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  20. Thrombophilia and Recurrent Pregnancy Loss: The Enigma Continues.Medical science monitor : international medical journal of experimental and clinical research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mahdieh KamaliDepartment of Perinatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Sedigheh HantoushzadehDepartment of Perinatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Sedigheh BornaMaternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
Hossein NeamatzadehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mahta MazaheriDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mahmood Noori-ShadkamMother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fatemeh HaghighiDepartment of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Shahid Sadoughi University of Medical Sciences and Health Services · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Studies have indicated that thrombophilic genes polymorphisms are associated with recurrent pregnancy loss (RPL) in the Iranian population. However, the results from these studies remained inconsistent and inconclusive. The aim of this systematic review and meta-analysis was to evaluate the precise association between thrombophilic genes polymorphisms (MTHFR C677T, MTHFR A1298C, Prothrombin G20210A, FVL G1691A, and PAI-1 4G/5G) and RPL risk in the Iranian population. Method: Electronic databases of PubMed, Web of Science, Google Scholar, and ISC were searched for eligible articles published up to April 1, 2017. The association between genetic polymorphisms and RPL risk was measured by ORs with 95% CI. Results: A total of 37 case-control studies in 18 relevant publications were selected in the final meta-analysis, including 1,199 RPL cases and 1,079 controls for MTHFR C677T, 1,194 RPL cases and 1079 controls for MTHFR A1298C, 630 RPL cases and 594 controls for Prothrombin G20210A, 830 RPL cases and 794 controls for FVL G1691A, and 955 RPL cases and 499 controls for PAI-1 4G/5G. When all the eligible studies were pooled into the meta-analysis of MTHFR C677T and A1298C polymorphisms, a significant increased risk of RPL was observed in all genetic models in the population. In addition, Prothrombin G20210A (in allelic and dominant models), FVL G1691A (in allelic and dominant model), and PAI-1 4G/5G (in allelic, homozygote, dominant and recessive genetic models) polymorphisms were associated with RPL risk in the Iranian population. Conclusion: The findings suggest that the thrombophilic genes polymorphisms are associated with an increased RPL risk in the Iranian population.

Indexed as

Factor V leidenMeta-analysisProthrombinRecurrent miscarriageThrombophilia

Identifiers

PMID28734273
PMCPMC5786662
OpenAlexW2759263520

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.