Evidence map›Paper›PMID 28742013›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie2017

First Canadian experience with donation after cardiac death simultaneous pancreas and kidney transplants.

Patrick T Anderson, Shahid Aquil, Kelly McLean, Vivian C McAlister, Alp Sener, Patrick P Luke

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Sterile Pancreas Inflammation during Preservation and after Transplantation.International journal of molecular sciences · 2023
    Review
  4. Article
  5. First World Consensus Conference on pancreas transplantation: Part II - recommendations.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  6. The history of renal transplantation in Canada: A urologic perspective.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Patrick T AndersonFrom the Department of Surgery, Division of Urology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont. (Anderson); the Western University Schulich School of Medicine and Dentistry, London, Ont. (McAlister, Sener, Luke); the Department of Surgery, Western University, London, Ont. (Aquil, McLean, McAlister, Sener, Luke); and the Multi-Organ Transplant Program, London Health Sciences Centre, London, Ont. (Aquil, McLean, McAlister, Sener, Luke).
Shahid AquilFrom the Department of Surgery, Division of Urology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont. (Anderson); the Western University Schulich School of Medicine and Dentistry, London, Ont. (McAlister, Sener, Luke); the Department of Surgery, Western University, London, Ont. (Aquil, McLean, McAlister, Sener, Luke); and the Multi-Organ Transplant Program, London Health Sciences Centre, London, Ont. (Aquil, McLean, McAlister, Sener, Luke).
Kelly McLeanFrom the Department of Surgery, Division of Urology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont. (Anderson); the Western University Schulich School of Medicine and Dentistry, London, Ont. (McAlister, Sener, Luke); the Department of Surgery, Western University, London, Ont. (Aquil, McLean, McAlister, Sener, Luke); and the Multi-Organ Transplant Program, London Health Sciences Centre, London, Ont. (Aquil, McLean, McAlister, Sener, Luke).
Vivian C McAlisterFrom the Department of Surgery, Division of Urology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont. (Anderson); the Western University Schulich School of Medicine and Dentistry, London, Ont. (McAlister, Sener, Luke); the Department of Surgery, Western University, London, Ont. (Aquil, McLean, McAlister, Sener, Luke); and the Multi-Organ Transplant Program, London Health Sciences Centre, London, Ont. (Aquil, McLean, McAlister, Sener, Luke).
Alp SenerFrom the Department of Surgery, Division of Urology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont. (Anderson); the Western University Schulich School of Medicine and Dentistry, London, Ont. (McAlister, Sener, Luke); the Department of Surgery, Western University, London, Ont. (Aquil, McLean, McAlister, Sener, Luke); and the Multi-Organ Transplant Program, London Health Sciences Centre, London, Ont. (Aquil, McLean, McAlister, Sener, Luke).
Patrick P LukeFrom the Department of Surgery, Division of Urology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont. (Anderson); the Western University Schulich School of Medicine and Dentistry, London, Ont. (McAlister, Sener, Luke); the Department of Surgery, Western University, London, Ont. (Aquil, McLean, McAlister, Sener, Luke); and the Multi-Organ Transplant Program, London Health Sciences Centre, London, Ont. (Aquil, McLean, McAlister, Sener, Luke).
Ottawa Hospital · CAWestern University · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCompared with neurologic determination of death (NDD) donor organs, donation after cardiac death (DCD) donor organs have traditionally been considered of inferior quality owing to warm ischemia experienced during procurement. We present, to our knowledge, the first analysis of simultaneous pancreas and kidney (SPK) transplants using DCD donor organs in Canada.

methodsWe carried out a retrospective cohort study of SPK transplants from 13 DCD and 68 NDD donors performed between October 2008 and July 2016. In all patients immunosuppression was induced with thymoglobulin and continued with tacrolimus, mycophenolate mofetil and prednisone maintenance therapy.

resultsDonor and recipient characteristics of DCD and NDD groups were similar with respect to age, sex, body mass index, kidney and pancreas cold ischemia times, and donor terminal creatinine. Mean DCD graft warm ischemia time was 0.5 (range 0.4-0.7) hours. Median follow-up was 2.2 (range 0.1-6.7) years and 2.7 (range 0.3-6.3) years for the DCD and NDD groups, respectively. The DCD and NDD groups were similar with regards to recipient percent panel reactive antibody and presence of human leukocyte antigen antibodies. The groups also received similar total doses of thymoglobulin. In total 38% of patients in the DCD group experienced renal delayed graft function (DGF) compared with 10% in the NDD group (

conclusionOur results show that, apart from a higher renal DGF rate, SPK transplants with DCD donor organs have comparable outcomes to standard transplants with NDD donor organs.

Indexed as

DeathAdultAntilymphocyte SerumFemaleFollow-Up StudiesHumansImmunosuppressive AgentsKidney TransplantationMaleMiddle AgedOutcome Assessment, Health CarePancreas TransplantationPostoperative ComplicationsRetrospective StudiesTissue DonorsAntilymphocyte SerumImmunosuppressive Agentsthymoglobulin

Identifiers

PMID28742013
PMCPMC5608581
OpenAlexW2760806621

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.