SynthesisPloS one2017
Pancreatic size and fat content in diabetes: A systematic review and meta-analysis of imaging studies.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset.Diabetes care · 2019Trial
- Pancreatic Morphological Patterns on MRI in Individuals With Suspected Type 5 Diabetes: An Exploratory Case Series From Mzuzu Central hospital, Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2026Article
- Pancreas Size and Fat Content Increase during Pregnancy and Correlate with Glycemic Control.American journal of perinatology · 2026Article
- Lifespan Pancreas Morphology for Control Versus Type 2 Diabetes Using AI on Largescale Clinical Imaging.Clinical anatomy (New York, N.Y.) · 2026Article
- Pancreatic steatosis is not associated with advanced steatohepatitis or fibrosis in metabolic dysfunction-associated steatotic liver disease.World journal of gastroenterology · 2025Article
- β-Cell Mass in Individuals With and Without Postbariatric Hypoglycemia After Roux-en-Y Gastric Bypass.Diabetes · 2025Article
- The impact of the recent HIV non-nucleoside reverse transcriptase inhibitors and nucleoside reverse transcriptase inhibitors-based regimens on metabolic health outcomes: A narrative review.Biochemistry and biophysics reports · 2025Review
- Determinants of Pancreatic Size and Fat Content in the UK Biobank: Influence of Race, Genetic Variants, and Risk Factors.The Journal of clinical endocrinology and metabolism · 2025Article
- Association of Pancreas Volume With Adverse Clinical Outcomes.Journal of the American Heart Association · 2025Article
- Adiposity, mortality, and disease risk: insights from bioimpedance analysis and magnetic resonance imaging.BMC medicine · 2025Article
- Alterations of the pancreas in type 1 diabetes - from prior to diagnosis to long-standing disease.Endocrine · 2025Article
- Article
- Automated pancreatic extracellular volume fraction as a biomarker for microangiopathy in type 2 diabetes mellitus.BMC medical imaging · 2025Article
- Pancreatic volume, fat content and T1 relaxation time using magnetic resonance imaging in patients with prior gestational diabetes mellitus.Abdominal radiology (New York) · 2025Article
- Multiorgan Imaging for Interorgan Crosstalk in Cardiometabolic Diseases.Circulation research · 2025Review
- Pancreatic Volume in Thalassemia: Determinants and Association with Alterations of Glucose Metabolism.Diagnostics (Basel, Switzerland) · 2025Article
- Multiparametric Magnetic Resonance Imaging Findings of the Pancreas: A Comparison in Patients with Type 1 and 2 Diabetes.Tomography (Ann Arbor, Mich.) · 2025Article
- Morphological and functional alterations in type 2 diabetes pancreata assessed with MRI-based metrics and [Frontiers in endocrinology · 2025Article
- A mathematical model of insulin action on acinar tissue linking histology and radiological imaging of the pancreas.Frontiers in endocrinology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesImaging studies are expected to produce reliable information regarding the size and fat content of the pancreas. However, the available studies have produced inconclusive results. The aim of this study was to perform a systematic review and meta-analysis of imaging studies assessing pancreas size and fat content in patients with type 1 diabetes (T1DM) and type 2 diabetes (T2DM).
methodsMedline and Embase databases were performed. Studies evaluating pancreatic size (diameter, area or volume) and/or fat content by ultrasound, computed tomography, or magnetic resonance imaging in patients with T1DM and/or T2DM as compared to healthy controls were selected. Seventeen studies including 3,403 subjects (284 T1DM patients, 1,139 T2DM patients, and 1,980 control subjects) were selected for meta-analyses. Pancreas diameter, area, volume, density, and fat percentage were evaluated.
resultsPancreatic volume was reduced in T1DM and T2DM vs. controls (T1DM vs. controls: -38.72 cm3, 95%CI: -52.25 to -25.19, I2 = 70.2%, p for heterogeneity = 0.018; and T2DM vs. controls: -12.18 cm3, 95%CI: -19.1 to -5.25, I2 = 79.3%, p for heterogeneity = 0.001). Fat content was higher in T2DM vs. controls (+2.73%, 95%CI 0.55 to 4.91, I2 = 82.0%, p for heterogeneity<0.001).
conclusionsIndividuals with T1DM and T2DM have reduced pancreas size in comparison with control subjects. Patients with T2DM have increased pancreatic fat content.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.