Evidence map›Paper›PMID 28742983›Full record

SynthesisHuman vaccines & immunotherapeutics2017

Should adults with diabetes mellitus be vaccinated against hepatitis B virus? A systematic review of diabetes mellitus and the progression of hepatitis B disease.

Zobair Younossi, Katrin Kochems, Marc de Ridder, Desmond Curran, Eveline M Bunge, Laurence de Moerlooze

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Diabetes Mellitus is a Risk Factor for Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Virus Infection in China.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Zobair Younossia Center for Liver Disease, Department of Medicine , Inova Fairfax Hospital , Falls Church , VA , USA.
Katrin Kochemsb Pallas Health Research and Consultancy , Rotterdam , The Netherlands.
Marc de Ridderc Faculté de Pharmacie, Université Libre de Bruxelles , Bruxelles , Belgium.
Desmond Currand GSK , Wavre , Belgium.
Eveline M Bungeb Pallas Health Research and Consultancy , Rotterdam , The Netherlands.
Laurence de Moerloozed GSK , Wavre , Belgium.
GlaxoSmithKline (Belgium) · BEInova Fairfax Hospital · USUniversité Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the burden of diabetes mellitus (DM), little is known about the role of this and other metabolic syndromes on the severity of hepatitis B virus (HBV) chronicity and liver disease progression. The value of hepatitis B vaccination and its impact on liver diseases and HCC has been largely demonstrated, adult vaccination coverage is however suboptimal and DM diagnosis represents an opportunity for the HCP to discuss hepatitis B and other adult vaccinations. We performed a systematic literature search to identify studies (January 2000 to January 2017) describing liver disease progression among patients with HBV by DM status. Risk factors were assessed including the relationship between HBV and non-alcoholic steatohepatitis (NASH). Data were extracted systematically and assessed descriptively. Twenty articles described liver disease progression and one article evaluated NASH among subjects with HBV by DM status. Fourteen articles reported that DM as a predictor for the outcome, including delayed seroclearance, cirrhosis, hepatocellular carcinoma, transplant/mortality and death, whereas no association on liver outcomes was found in 7 studies. In summary, our review suggests that DM is associated with the progression of severe liver outcomes in adults with HBV, although more studies are needed to understand the benefits of HBV vaccination in adults with DM and liver-diseases.

Indexed as

Disease ProgressionAdultCarcinoma, HepatocellularDiabetes Mellitus, Type 2FemaleHepatitis BHepatitis B, ChronicHepatitis B VaccinesHepatitis B virusHumansLiver CirrhosisLiver NeoplasmsMaleMiddle AgedRisk FactorsVaccination CoverageHepatitis B Vaccinescirrhosisdiabetes mellitushepatitis Bhepatitis B virushepatocellular carcinomaliver diseaseNASHsystematicType 2 diabetes mellitus

Identifiers

PMID28742983
PMCPMC5703367
OpenAlexW2737602736

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.