Evidence map›Paper›PMID 28744255›Full record

ArticleFrontiers in endocrinology2017

Glycemic and Metabolic Effects of Two Long Bouts of Moderate-Intensity Exercise in Men with Normal Glucose Tolerance or Type 2 Diabetes.

Saeed Reza Eshghi, Kevin Fletcher, Étienne Myette-Côté, Cody Durrer, Raniah Q Gabr, Jonathan P Little, Peter Senior, Craig Steinback, Margie H Davenport, Gordon J Bell and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Saeed Reza EshghiFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Kevin FletcherFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Étienne Myette-CôtéFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Cody DurrerSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada.
Raniah Q GabrNational Organization for Drug Control and Research (NODCAR), Giza, Egypt.
Jonathan P LittleSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada.
Peter SeniorAlberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
Craig SteinbackFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Margie H DavenportFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Gordon J BellFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
Dion R BrocksFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Normand G BouléFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CAUniversity of British Columbia · CANational Organization for Drug Control and Research · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe glycemic and insulinemic responses following 30-60 min of exercise have been extensively studied, and a dose-response has been proposed between exercise duration, or volume, and improvements in glucose tolerance or insulin sensitivity. However, few studies have examined the effects of longer bouts of exercise in type 2 diabetes (T2D). Longer bouts may have a greater potential to affect glucagon, interleukin-6 (IL-6) and incretin hormones [i.e., glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)].

aimTo examine the effect of two bouts of long-duration, moderate-intensity exercise on incretins, glucagon, and IL-6 responses before and after exercise, as well as in response to an oral glucose tolerance test (OGTT) conducted the following day.

methodsTwelve men, six with and six without T2D, participated in two separate conditions (i.e., exercise vs. rest) according to a randomized crossover design. On day 1, participants either rested or performed two 90 min bouts of treadmill exercise (separated by 3.5 h) at 80% of their ventilatory threshold. All participants received standardized meals on day 1. On day 2 of each condition, glucose and hormonal responses were measured during a 4-h OGTT.

resultsOn day 1, exercise increased IL-6 at the end of the first bout of exercise (exercise by time interaction

conclusionLong-duration, moderate-intensity aerobic exercise can increase IL-6. On the day following exercise, fasting incretins remained increased but postprandial insulin and glucagon were decreased without affecting postprandial glucose. This long duration of exercise may not be appropriate for some people, and further research should investigate why next day glucose tolerance was unchanged.

Indexed as

aerobic exerciseglucagonglucagon-like peptide-1glucose-dependent insulinotropic peptideglucose toleranceinsulin

Identifiers

PMID28744255
PMCPMC5504214
OpenAlexW2735160054

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.