ArticleJournal of ophthalmology2017
Parafoveal OCT Angiography Features in Diabetic Patients without Clinical Diabetic Retinopathy: A Qualitative and Quantitative Analysis.
Article in Journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04215445 (Effect of Sodium Glucose co Transporter 2), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Sodium Glucose co Transporter 2 (SGLT2) Inhibition on Optical Coherence Tomography Angiography (OCT-A) Parameters in Diabetic Chronic Kidney Disease (CKD)
Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Macular Pigment Changes in Patients with Diabetes Mellitus and Without Diabetic Retinopathy.Ophthalmology and therapy · 2026Article
- Volumetric Measures of Capillary Nonperfusion on Optical Coherence Tomography Angiography Detect Early Ischemia in Diabetes Without Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Early Diabetic Retinopathy Evaluation With OCTA: A Study on Vascular Branching and Fragmentation.Investigative ophthalmology & visual science · 2024Article
- Quantitative assessment of OCT and OCTA parameters in diabetic retinopathy with and without macular edema: single-center cross-sectional analysis.Frontiers in endocrinology · 2023Article
- Perspectives on diabetic retinopathy from advanced retinal vascular imaging.Eye (London, England) · 2022Review
- Compensatory contribution of retinal larger vessels to perfusion density in diabetics without retinopathy.Scientific reports · 2022Article
- Retinal Neurodegeneration in Diabetes: an Emerging Concept in Diabetic Retinopathy.Current diabetes reports · 2021Review
- Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy.Journal of clinical medicine · 2020Review
- Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Microvascular Changes in the Choriocapillaris of Diabetic Patients Without Retinopathy Investigated by Swept-Source OCT Angiography.Investigative ophthalmology & visual science · 2020Article
- Association Between Clinical Biomarkers and Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes Mellitus.Investigative ophthalmology & visual science · 2020Article
- Quantitative optical coherence tomography angiography: A review.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Optical coherence tomography angiography (OCTA) flow speed mapping technology for retinal diseases.Expert review of medical devices · 2018Review
- Assessment of capillary dropout in the superficial retinal capillary plexus by optical coherence tomography angiography in the early stage of diabetic retinopathy.BMC ophthalmology · 2018Observational
- Analysis of Foveal Microvascular Abnormalities in Diabetic Retinopathy Using Optical Coherence Tomography Angiography with Projection Artifact Removal.Journal of ophthalmology · 2018Article
- Risk factors for retinal microvascular impairment in type 2 diabetic patients without diabetic retinopathy.PloS one · 2018 · on this mapArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the capacity of OCT angiography (OCTA) for detecting infraclinical lesions in parafoveal capillaries in diabetic patients without diabetic retinopathy (DR).
methodsThis prospective observational cross-sectional case-control study analyzed the superficial and deep capillary plexuses (SCP and DCP) on macular OCTA scans (3 × 3 mm) centered on the fovea. We compared 22 diabetic patients (34 eyes included) without DR diagnosis on color fundus photographs, with 22 age- and gender-matched nondiabetic controls (40 eyes included). Qualitative analysis concerned morphological ischemic capillary alterations. Quantitative analysis measured foveal avascular zone (FAZ) size, parafoveal capillary density, and enlargement coefficient of FAZ between SCP and DCP.
resultsNeither the qualitative nor quantitative parameters were significantly different between both groups. No microaneurysms or venous tortuosity was observed in any of the analyzed images. On the SCP, the mean FAZ area was 0.322 ± 0.125 mm
conclusionOCTA did not detect infraclinical qualitative or quantitative differences in parafoveal capillaries of diabetic patients without DR in comparison with nondiabetic controls.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.