ArticleMaterials (Basel, Switzerland)2017
Biocompatibility and Inflammatory Potential of Titanium Alloys Cultivated with Human Osteoblasts, Fibroblasts and Macrophages.
Article in Materials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Is titanium alloy Ti-6Al-4 V cytotoxic to gingival fibroblasts-A systematic review.Clinical and experimental dental research · 2021Pooled it
- Structure-property correlation study on biocompatibility of wire arc additively manufactured nitinol alloy.iScience · 2026Article
- Advances in Titanium-Based Biomaterial for Human Bone Scaffolds: Narrative Review on Design, Fabrication, Surface Engineering, Implantation, and Biological Evaluation.Materials (Basel, Switzerland) · 2025Review
- Feasibility of a Shape-Memory-Alloy-Actuator System for Modular Acetabular Cups.Bioengineering (Basel, Switzerland) · 2024Article
- Multifunctional coatings of nickel-titanium implant toward promote osseointegration after operation of bone tumor and clinical application: a review.Frontiers in bioengineering and biotechnology · 2024Review
- Titanium alloys with varying surface micro-area potential differences have antibacterial abilities and a favorable cellular response.Clinical oral investigations · 2023Article
- In Vitro Evaluation of the Potential Anticancer Properties of Cu-Based Shape Memory Alloys.Materials (Basel, Switzerland) · 2023Article
- Experimental Investigation of the Biofunctional Properties of Nickel-Titanium Alloys Depending on the Type of Production.Molecules (Basel, Switzerland) · 2022Article
- Functionalization of screw implants with superelastic structured Nitinol anchoring elements.Biomedical engineering online · 2022Article
- Investigation into the Hybrid Production of a Superelastic Shape Memory Alloy with Additively Manufactured Structures for Medical Implants.Materials (Basel, Switzerland) · 2021Article
- Preclinical In Vitro Assessment of Submicron-Scale Laser Surface Texturing on Ti6Al4V.Materials (Basel, Switzerland) · 2020Article
- Establishment and Evaluation of an In Vitro System for Biophysical Stimulation of Human Osteoblasts.Cells · 2020Article
- Article
- Biological Cell Investigation of Structured Nitinol Surfaces for the Functionalization of Implants.Materials (Basel, Switzerland) · 2020Article
- The development of novel bioactive porous titanium as a bone reconstruction material.RSC advances · 2020Article
- New Pre-reacted Glass Containing Dental Composites (giomers) with Improved Fluoride Release and Biocompatibility.Materials (Basel, Switzerland) · 2019Article
- The Preparation and Properties of Multilayer Cu-MTaNanomaterials (Basel, Switzerland) · 2019Article
- Adhesion Behaviour of Primary Human Osteoblasts and Fibroblasts on Polyether Ether Ketone Compared with Titanium under In Vitro Lipopolysaccharide Incubation.Materials (Basel, Switzerland) · 2019Article
- Comparison of different cell culture plates for the enrichment of non-adherent human mononuclear cells.Experimental and therapeutic medicine · 2019Article
- Understanding the effects of PBF process parameter interplay on Ti-6Al-4V surface properties.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biomaterials used to maintain or replace functions in the human body consist mainly of metals, ceramics or polymers. In orthopedic surgery, metallic materials, especially titanium and its alloys, are the most common, due to their excellent mechanical properties, corrosion resistance, and biocompatibility. Aside from the established Ti6Al4V alloy, shape memory materials such as nickel-titanium (NiTi) have risen in importance, but are also discussed because of the adverse effects of nickel ions. These might be reduced by specific surface modifications. In the present in vitro study, the osteoblastic cell line MG-63 as well as primary human osteoblasts, fibroblasts, and macrophages were cultured on titanium alloys (forged Ti6Al4V, additive manufactured Ti6Al4V, NiTi, and Diamond-Like-Carbon (DLC)-coated NiTi) to verify their specific biocompatibility and inflammatory potential. Additive manufactured Ti6Al4V and NiTi revealed the highest levels of metabolic cell activity. DLC-coated NiTi appeared as a suitable surface for cell growth, showing the highest collagen production. None of the implant materials caused a strong inflammatory response. In general, no distinct cell-specific response could be observed for the materials and surface coating used. In summary, all tested titanium alloys seem to be biologically appropriate for application in orthopedic surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.