ArticleEuropean journal of nuclear medicine and molecular imaging2017
18F-FDG PET diagnostic and prognostic patterns do not overlap in Alzheimer's disease (AD) patients at the mild cognitive impairment (MCI) stage.
Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Correspondence of Basal Forebrain Resting-State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease.CNS neuroscience & therapeutics · 2026Article
- Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing.Scientific reports · 2025Article
- BrainEpilepsia · 2025Article
- Imaging biomarkers of cortical neurodegeneration underlying cognitive impairment in Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2025Article
- The impact of tau deposition and hypometabolism on cognitive impairment and longitudinal cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Prognostic value of imaging-based ATN profiles in a memory clinic cohort.European journal of nuclear medicine and molecular imaging · 2023Article
- Validation of the REM behaviour disorder phenoconversion-related pattern in an independent cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- PET molecular imaging for pathophysiological visualization in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2023Review
- Associations of digital neuro-signatures with molecular and neuroimaging measures of brain resilience: The altoida large cohort study.Frontiers in psychiatry · 2022Article
- In vivo synaptic density relates to glucose metabolism at rest in healthy subjects, but is strongly modulated by regional differences.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Brain Metabolic Correlates of Persistent Olfactory Dysfunction after SARS-Cov2 Infection.Biomedicines · 2021Article
- Data-driven FDG-PET subtypes of Alzheimer's disease-related neurodegeneration.Alzheimer's research & therapy · 2021Article
- CSF p-tau/AβEuropean journal of nuclear medicine and molecular imaging · 2020Article
- Impacts of CR1 genetic variants on cerebrospinal fluid and neuroimaging biomarkers in alzheimer's disease.BMC medical genetics · 2020Article
- Spinal cord hypermetabolism extends to skeletal muscle in amyotrophic lateral sclerosis: a computational approach to [18F]-fluorodeoxyglucose PET/CT images.EJNMMI research · 2020Article
- Metabolic covariance networks combining graph theory measuring aberrant topological patterns in mesial temporal lobe epilepsy.CNS neuroscience & therapeutics · 2019Article
- Spatial distributions of cholinergic impairment and neuronal hypometabolism differ in MCI due to AD.NeuroImage. Clinical · 2019Article
- Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis.Brain : a journal of neurology · 2018Article
- Amyloid and tau signatures of brain metabolic decline in preclinical Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2018Article
- Metabolic correlates of reserve and resilience in MCI due to Alzheimer's Disease (AD).Alzheimer's research & therapy · 2018Article
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to identify the cortical regions where hypometabolism can predict the speed of conversion to dementia in mild cognitive impairment due to Alzheimer's disease (MCI-AD).
methodsWe selected from the clinical database of our tertiary center memory clinic, eighty-two consecutive MCI-AD that underwent 18F-fluorodeoxyglucose (FDG) PET at baseline during the first diagnostic work-up and were followed up at least until their clinical conversion to AD dementia. The whole group of MCI-AD was compared in SPM8 with a group of age-matched healthy controls (CTR) to verify the presence of AD diagnostic-pattern; then the correlation between conversion time and brain metabolism was assessed to identify the prognostic-pattern. Significance threshold was set at p < 0.05 False-Discovery-Rate (FDR) corrected at peak and at cluster level. Each MCI-AD was then compared with CTR by means of a SPM single-subject analysis and grouped according to presence of AD diagnostic-pattern and prognostic-pattern. Kaplan-Meier-analysis was used to evaluate if diagnostic- and/or prognostic-patterns can predict speed of conversion to dementia.
resultsDiagnostic-pattern corresponded to typical posterior hypometabolism (BA 7, 18, 19, 30, 31 and 40) and did not correlate with time to conversion, which was instead correlated with metabolic levels in right middle and inferior temporal gyri as well as in the fusiform gyrus (prognostic-pattern, BA 20, 21 and 38). At Kaplan-Meier analysis, patients with hypometabolism in the prognostic pattern converted to AD-dementia significantly earlier than patients not showing significant hypometabolism in the right middle and inferior temporal cortex (9 versus 19 months; Log rank p < 0.02, Breslow test: p < 0.003, Tarone-Ware test: p < 0.007).
conclusionThe present findings support the role of FDG PET as a robust progression biomarker even in a naturalist population of MCI-AD. However, not the AD-typical diagnostic-pattern in posterior regions but the middle and inferior temporal metabolism captures speed of conversion to dementia in MCI-AD since baseline. The highlighted prognostic pattern is a further, independent source of heterogeneity in MCI-AD and affects a primary-endpoint on interventional clinical trials (time of conversion to dementia).
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