ArticleMolecular medicine reports2017
Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Metastatic Hypopharyngeal Carcinoma Involving the Stomach: A Case Report and Literature Review.Cureus · 2026Article
- The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly.Cells · 2022Article
- Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation.Journal of extracellular vesicles · 2022Article
- Knockdown of Long Noncoding RNA 01124 Inhibits the Malignant Behaviors of Colon Cancer Cells via miR-654-5p/HAX-1.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.Thoracic cancer · 2020Article
- Clinical significance of COL1A1 and COL1A2 expression levels in hypopharyngeal squamous cell carcinoma.Oncology letters · 2020Article
- HAX-1 overexpression in gastric cancer promotes cell proliferation.Translational cancer research · 2020Article
- miR-654-5p Targets HAX-1 to Regulate the Malignancy Behaviors of Colorectal Cancer Cells.BioMed research international · 2020Article
- Cytoplasmic HAX1 Is an Independent Risk Factor for Breast Cancer Metastasis.Journal of oncology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HCLS1‑associated protein X‑1 (HAX‑1) is highly expressed or overexpressed in various types of human tumor, and its overexpression is associated with cancer metastasis and cellular proliferation. However, the precise molecular mechanism involved in HAX‑1‑associated proliferation and metastasis in hypopharyngeal carcinoma is unknown. The present study aimed to investigate the role of HAX‑1 in the metastasis and proliferation of hypopharyngeal carcinoma. Reverse transcription‑quantitative polymerase chain reaction analysis and western blotting indicated that HAX‑1 was overexpressed in hypopharyngeal carcinoma specimens. MTT, clone formation and transwell assays were performed to detect the effects of HAX‑1 knockdown or overexpression on the major oncogenic properties of the FaDu hypopharyngeal carcinoma cell line. Downregulation of HAX‑1 was observed to significantly suppress cellular proliferation, migration and clonal. By contrast, overexpression of HAX‑1 significantly promoted cellular proliferation, migration and clonal formation. Furthermore, HAX‑1 knockdown markedly suppressed epithelial‑mesenchymal transition. In conclusion, HAX‑1 is a potential oncogene, and may promote the tumorigenesis and progression of hypopharyngeal carcinoma, as well as serve as a valuable molecular target for the treatment of hypopharyngeal carcinoma.
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