Evidence map›Paper›PMID 28808889›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019

Interactions between myocardial sympathetic denervation and left ventricular mechanical dyssynchrony: A CZT analysis.

Alessia Gimelli, Riccardo Liga, Francesca Menichetti, Ezio Soldati, Maria Grazia Bongiorni, Paolo Marzullo

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Evaluation of dyssynchrony with nuclear cardiac imaging: New evidence for an old parameter.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  5. Cardiac sympathetic dysfunction in left ventricular hypertrophy caused by arterial hypertension and degenerative aortic stenosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  6. Perspective and future direction of intraventricular mechanical dyssynchrony assessment.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  7. Beware the pitfalls of beauty: High-quality myocardial images with resolution recovery.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Article
  8. Review
  9. Neuronal damage and abnormal contraction: Is the circle of synchronicity complete?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  10. Phase dyssynchrony andJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Alessia GimelliFondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy. gimelli@ftgm.it.
Riccardo LigaUniversity of Pisa, Pisa, Italy.
Francesca MenichettiCardio-Thoracic and Vascular department, University Hospital of Pisa, Pisa, Italy.
Ezio SoldatiCardio-Thoracic and Vascular department, University Hospital of Pisa, Pisa, Italy.
Maria Grazia BongiorniCardio-Thoracic and Vascular department, University Hospital of Pisa, Pisa, Italy.
Paolo MarzulloFondazione Toscana Gabriele Monasterio, Via Moruzzi, 1, 56124, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA correlation between left ventricular (LV) dyssynchrony (LVD) and impaired myocardial sympathetic tone has been hypothesized. We sought to assess the interactions between regional LV sympathetic innervation, perfusion, and mechanical dyssynchrony.

methodsEighty-three patients underwent evaluation of LV perfusion and sympathetic innervation on

resultsLVD was revealed in 36 (43%) patients. Patients with LVD had more abnormal values of SRS (21 ± 9 vs 10 ± 8, P < 0.001) and SS-MIBG (29 ± 9 vs 17 ± 11, P < 0.001) than those without LVD. The presence of LVD also clustered with a higher burden of "innervation/perfusion" mismatch (P = 0.019). On per-wall analysis, LV walls with delayed mechanical activation showed a higher burden of "innervation/perfusion" mismatch (2.3 ± 1.4 segments) than normally contracting walls (1.3 ± 1.2 segments; P < 0.001). On multivariate analysis, the extent of "innervation/perfusion" mismatch was the only predictor of delayed mechanical activation (P = 0.029).

conclusionsPatients with LVD show an elevated burden of "innervation/perfusion" mismatch that is concentrated at the level of the most dyssynchronous walls.

Indexed as

CadmiumSympathectomyTelluriumZinc3-IodobenzylguanidineAgedFemaleHeartHeart VentriclesHumansMaleMiddle AgedMyocardial Perfusion ImagingMyocardiumOrganophosphorus CompoundsOrganotechnetium Compounds3-IodobenzylguanidineCadmiumCdZnTeOrganophosphorus CompoundsOrganotechnetium Compoundstechnetium tc-99m tetrofosminTelluriumZinc123I-metaiodobenzylguanidineCZTinnervation/perfusion mismatchleft ventricular dyssynchronyphase analysis

Identifiers

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.