ArticleCell reports2017
Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability.
Open access · goldAbstract read
In one paragraph
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 99 citations in OpenAlex.
- The role of FGF19-FGFR4 signaling pathway in liver health and disease: Guardian or destroyer.Genes & diseases · 2026Review
- Reprogramming FGFR isoform specificity in FGF2 by deep mutational scanning.Chemical science · 2026Article
- Mechanisms and Manifestations of Ligand Bias in Signaling: Focus on Receptor Tyrosine Kinases.Chemical reviews · 2026Review
- Structure-function relationship in FGF signaling: rational design of highly stable FGF2 variants and their effect on cell growth, metabolism, and survival.Journal of biological engineering · 2026Article
- Human FGF1Cells · 2026Article
- Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney.World journal of diabetes · 2026Article
- FGF1 ameliorates hepatic steatosis through acute activation of the unfolded protein response and VLDL production.JHEP reports : innovation in hepatology · 2026Article
- Engineered fibroblast growth factor 1 variants uncouple glucose-lowering effects from mitogenic activity with therapeutic potential for type 2 diabetes.Molecular biomedicine · 2026Article
- Developing FGF2 Mutants with Selectively Reduced Heparan Sulfate Affinity to Explore their Impact on FGFR1 Signaling.Chembiochem : a European journal of chemical biology · 2025Article
- Development of FGF21 Mutant with Potent Cardioprotective Effects in T2D Mice via FGFR1-AMPK-Mediated Inhibition of Oxidative Stress.International journal of molecular sciences · 2025Article
- FGF-based drug discovery: advances and challenges.Nature reviews. Drug discovery · 2025Review
- Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease.Nature communications · 2025Article
- Pathology and Therapeutic Significance of Fibroblast Growth Factors.Targets (Basel) · 2025Article
- Hepatocyte-Derived FGF1 Alleviates Isoniazid and Rifampicin-Induced Liver Injury by Regulating HNF4α-Mediated Bile Acids Synthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fibroblast Growth Factors: Roles and Emerging Therapeutic Applications.Current drug targets · 2025Review
- Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance.Biomolecules · 2024Review
- FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune hepatitis.Journal of translational medicine · 2024Article
- The AMPK and AKT/GSK3β pathways are involved in recombinant proteins fibroblast growth factor 1 (rFGF1 and rFGF1a) improving glycolipid metabolism in rainbow trout (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Hyperglycemia activates FGFR1Acta pharmaceutica Sinica. B · 2024Article
- Beneficial Effects of Fibroblast Growth Factor-1 on Retinal Pigment Epithelial Cells Exposed to High Glucose-Induced Damage: Alleviation of Oxidative Stress, Endoplasmic Reticulum Stress, and Enhancement of Autophagy.International journal of molecular sciences · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Zhifeng HuangSchool of Pharmacy & Center for Structural Biology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Yi TanSchool of Pharmacy & Center for Structural Biology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Pediatric Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Junlian GuPediatric Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA; Diabetes and Obesity Center, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Yang LiuDepartment of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Lintao SongSchool of Pharmacy & Center for Structural Biology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Jianlou NiuSchool of Pharmacy & Center for Structural Biology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Longwei ZhaoSchool of Pharmacy & Center for Structural Biology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Lakshmi SrinivasanDepartment of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
Qian LinSchool of Pharmacy & Center for Structural Biology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Pediatric Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Jingjing DengDepartment of Cell Biology and Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Yang LiAmgen, Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
Daniel J ConklinDiabetes and Obesity Center, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Thomas A NeubertDepartment of Cell Biology and Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Lu CaiPediatric Research Institute, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Xiaokun LiSchool of Pharmacy & Center for Structural Biology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: xiaokunli@wzmu.edu.cn.
Moosa MohammadiDepartment of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: moosa.mohammadi@nyumc.org.
New York University · USWenzhou Medical University · CNUniversity of Louisville · USAmgen (United States) · US
Funding
Project 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI · 2012 to 2017
$13.8MMECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALINGR01DE013686 · NIDCR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MOHAMMADI, MOOSA · 2000 to 2020
$12.3MProtein Mass Spectrometry Core Facility for NeuroscienceP30NS050276 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NEUBERT, THOMAS A · 2005 to 2015
$7.9MLTQ-Orbitrap Mass Spectrometer.S10RR027990 · NCRR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NEUBERT, THOMAS A · 2011 to 2011
$600kNCRR NIH HHS S10 RR027990NIDCR NIH HHS R01 DE013686NIGMS NIH HHS P20 GM103492NINDS NIH HHS P30 NS050276
Abstract
The recent discovery of metabolic roles for fibroblast growth factor 1 (FGF1) in glucose homeostasis has expanded the functions of this classically known mitogen. To dissect the molecular basis for this functional pleiotropy, we engineered an FGF1 partial agonist carrying triple mutations (FGF1
Indexed as
3T3-L1 CellsAnimalsBinding SitesCell Line, TumorCloning, MolecularEscherichia coliFibroblast Growth Factor 1Gene ExpressionHepatocytesHumansMiceMice, Inbred C57BLMitogensModels, MolecularNIH 3T3 CellsProtein BindingFibroblast Growth Factor 1MitogensReceptors, Fibroblast Growth FactorRecombinant Proteinsdb/db miceFGF receptorfibroblast growth factor 1glucose uptakeheparin sulfatemetabolismmitogenesisreceptor dimerizationsignaling pathwaysthreshold
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.