Evidence map›Paper›PMID 28824916›Full record

ReviewFrontiers in nutrition2017

Cocoa, Blood Pressure, and Vascular Function.

Valeria Ludovici, Jens Barthelmes, Matthias P Nägele, Frank Enseleit, Claudio Ferri, Andreas J Flammer, Frank Ruschitzka, Isabella Sudano

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Valeria LudoviciCardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland.
Jens BarthelmesCardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland.
Matthias P NägeleCardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland.
Frank EnseleitCardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland.
Claudio FerriDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Andreas J FlammerCardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland.
Frank RuschitzkaCardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland.
Isabella SudanoCardiology, University Heart Center, University Hospital and University of Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHUniversity of Zurich · CHUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease (CVD) represents the most common cause of death worldwide. The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke. Intervention studies strongly suggest that cocoa exerts a beneficial impact on cardiovascular health, through the reduction of blood pressure (BP), improvement of vascular function, modulation of lipid and glucose metabolism, and reduction of platelet aggregation. These potentially beneficial effects have been shown in healthy subjects as well as in patients with risk factors (arterial hypertension, diabetes, and smoking) or established CVD (coronary heart disease or heart failure). Several potential mechanisms are supposed to be responsible for the positive effect of cocoa; among them activation of nitric oxide (NO) synthase, increased bioavailability of NO as well as antioxidant, and anti-inflammatory properties. It is the aim of this review to summarize the findings of cocoa and chocolate on BP and vascular function.

Indexed as

arterial stiffnessblood pressurecocoaendothelial functionflavonoids

Identifiers

PMID28824916
PMCPMC5539137
OpenAlexW2734534332

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.