Evidence map›Paper›PMID 28826907›Full record

ReviewCellular signalling2017

Protein kinase C isoforms in the normal pancreas and in pancreatic disease.

Alicia K Fleming, Peter Storz

Open access · greenAbstract readReview
In one paragraph

Review in Cellular signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. The Role of MicroRNAs in Diabetes-Related Oxidative Stress.International journal of molecular sciences · 2019
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alicia K FlemingDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.
Peter StorzDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA. Electronic address: storz.peter@mayo.edu.
Mayo Clinic in Florida · US

Funding

PKD1 signaling in the initiation of pancreatic cancerR01CA200572 · NCI · MAYO CLINIC JACKSONVILLE · PI STORZ, PETER · 2016 to 2021
$1.8M
NCI NIH HHS R01 CA200572
6 · The paper itself

Abstract

Protein Kinase C isoforms have been implicated in regulating multiple processes within the healthy pancreas. Moreover, their dysregulation contributes to all aspects of pancreatic disease. In this review, with a focus on acinar, ductal, and islet cells, we highlight the roles and contributions of the different PKC isoforms to normal pancreas function. We also discuss the contribution of PKC enzymes to pancreatic diseases, including insulin resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer.

Indexed as

Diabetes MellitusHumansInsulin ResistancePancreasPancreatic NeoplasmsPancreatitisProtein IsoformsProtein Kinase CProtein IsoformsProtein Kinase CPancreasPancreatic cancerPancreatitisPKCProtein kinase C

Identifiers

PMID28826907
PMCPMC5651200
OpenAlexW2749479110

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.