Evidence map›Paper›PMID 28829048›Full record

ArticleImmunology and cell biology2017

Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent.

Shwetank, Hossam A Abdelsamed, Elizabeth L Frost, Heather M Schmitz, Taryn E Mockus, Ben A Youngblood, Aron E Lukacher

Open access · greenAbstract read
In one paragraph

Article in Immunology and cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 69 citations in OpenAlex.

  1. PD-1 regulates CD4Nature communications · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Alarm Functions of PD-1+ Brain-Resident Memory T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. CD8+ Tissue-Resident Memory T Cells: Versatile Guardians of the Tissue.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
  13. Review
  14. Tissue-resident immune cells in the pathogenesis of multiple sclerosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  15. Keeping T cell memories in mind.Trends in immunology · 2022
    Review
  16. Transcriptomic Profiling Identifies CD8Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

ShwetankDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0002-5069-603X
Hossam A AbdelsamedDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Elizabeth L FrostDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, USA.
Heather M SchmitzDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, USA.
Taryn E MockusDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, USA.
Ben A YoungbloodDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Aron E LukacherDepartment of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, USA.ORCID 0000-0002-7969-2841
Penn State Milton S. Hershey Medical Center · USSt. Jude Children's Research Hospital · USUniversity of Virginia · US

Funding

TRAINING IN IMMUNOLOGY AND MOLECULAR PATHOGENESIST32AI007610 · NIAID · EMORY UNIVERSITY · PI EVAVOLD, BRIAN D · 2000 to 2014
$4.4M
A Mouse Model to Define Immunovirologic Determinants of Polyomavirus CNS DiseaseR01NS088367 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LUKACHER, ARON ELIOT · 2014 to 2021
$2.8M
Epigenetic Regulation of T-cell Exhaustion During Treated Chronic HIV InfectionR01AI114442 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YOUNGBLOOD, BENJAMIN ALAN · 2015 to 2019
$2.1M
Pathogenesis of Mouse Polyomavirus-associated CNS DemyelinationR01NS092662 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LUKACHER, ARON ELIOT · 2016 to 2022
$2.1M
T-cell immunity to polyomavirus infectionR01AI102543 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LUKACHER, ARON ELIOT · 2012 to 2015
$1.5M
Development of a Mouse Model of Progressive Multifocal LeukoencephalopathyF31NS083336 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI FROST, ELIZABETH LEIGH · 2013 to 2015
$58k
NIAID NIH HHS R01 AI102543NIAID NIH HHS R01 AI114442NIAID NIH HHS T32 AI007610NINDS NIH HHS F31 NS083336NINDS NIH HHS R01 NS088367NINDS NIH HHS R01 NS092662
6 · The paper itself

Abstract

Infection of the central nervous system (CNS) by murine polyomavirus (MuPyV), a persistent natural mouse pathogen, establishes brain-resident memory CD8 T cells (bT

Indexed as

Adoptive TransferAnimalsBrainCD8-Positive T-LymphocytesCell DifferentiationCells, CulturedEpigenesis, GeneticEpitopes, T-LymphocyteFemaleGene Expression RegulationImmunologic MemoryMiceMice, Inbred C57BLMice, KnockoutPolyomavirusPolyomavirus InfectionsEpitopes, T-LymphocytePdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID28829048
PMCPMC5698165
OpenAlexW2745542733

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.