Evidence map›Paper›PMID 28830679›Full record

ArticleEuropean journal of pharmacology2017

Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta.

Brandi M Wynne, Hicham Labazi, Zidonia N Carneiro, Rita C Tostes, R Clinton Webb

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Brandi M WynneDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, United States; Department of Medicine, Renal Division, Emory University, 615 Michael St. Ste 605C, Atlanta, GA 30322, United States. Electronic address: bwynne@emory.edu.
Hicham LabaziDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, United States; Center for Cardiovascular Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43215, United States. Electronic address: Hicham.Labazi@nationwidechildrens.org.
Zidonia N CarneiroDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, United States. Electronic address: znunes@hotmail.com.
Rita C TostesPharmacology Department, Medical School of Ribeirão Preto, University of São Paulo, Av Bandeirantes 3900, Ribeirão Preto, SP 14049-900, Brazil. Electronic address: rtostes@usp.br.
R Clinton WebbDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA 30912, United States. Electronic address: CWEBB@augusta.edu.
Augusta University · USEmory University · USUniversidade de São Paulo · BR

Funding

Nitric Oxide Inhibits RhoA/Rho-kinase in Penile ErectionR01HL071138 · MEDICAL COLLEGE OF GEORGIA (MCG) · 2003 to 2005
$1.1M
NHLBI NIH HHS R01 HL071138
6 · The paper itself

Abstract

Nitroglycerin (Gtn) is a treatment for cardiovascular patients due to its vasodilatory actions, but induces tolerance when given chronically. A proposed mechanism is the superoxide (O

Indexed as

AnimalsAortaEndothelin-1MaleMiceNitritesNitrogen OxidesSinglet OxygenVasoconstrictionEndothelin-1NitritesNitrogen OxidesnitroxyloxyhyponitriteSinglet OxygenAngeli's SaltEndothelin-1HNONitroglycerinVascular dysfunction

Identifiers

PMID28830679
PMCPMC5777347
OpenAlexW2745426750

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.