ArticlePloS one2017
Cardiac computed tomography-derived epicardial fat volume and attenuation independently distinguish patients with and without myocardial infarction.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178145 (MRI of Epicardial Adipose Tissue Composition), which is not on this map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MRI of Epicardial Adipose Tissue Composition: Development of Methods and Application to Heart Failure With Preserved Ejection Fraction
Who cites it
54 citing papers in PubMed.
- The Natural history of Epicardial Adipose Tissue Volume and Attenuation: A long-term prospective cohort follow-up study.Scientific reports · 2020Trial
- Statins Reduce Epicardial Adipose Tissue Attenuation Independent of Lipid Lowering: A Potential Pleiotropic Effect.Journal of the American Heart Association · 2019Trial
- Cardiometabolic benefits of parathyroidectomy in dialysis patients with secondary hyperparathyroidism: preliminary insights from CT radiomics and body composition analysis.Renal failure · 2026Article
- Mediastinal adipose tissue as an active player in cardiovascular disease: a multimodality imaging narrative review.Quantitative imaging in medicine and surgery · 2026Review
- Epicardial adipose tissue in coronary microvascular disease.American heart journal plus : cardiology research and practice · 2026Review
- A modifiable imaging biomarker: epicardial adipose tissue density in ischemia with non-obstructive coronary arteries.Frontiers in cardiovascular medicine · 2026Article
- Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- AI-quantified epicardial adipose tissue and prediction of future myocardial infarction in patients with cardiometabolic disease: a post-hoc analysis from the SCOT-HEART trial.Cardiovascular diabetology · 2025Article
- Epicardial fat thickness predicts severe coronary artery disease and high mortality risk among ST-elevation myocardial infarction patients.Echo research and practice · 2025Article
- Sex Differences in Epicardial Adipose Tissue and Other Risk Factors for Coronary Artery Disease.Medicina (Kaunas, Lithuania) · 2025Article
- Pericoronary fat attenuation in stenotic and vulnerable coronary artery plaques: Implications for coronary artery disease and associated conditions.Acta radiologica open · 2025Article
- Chest-CT-based radiomics feature of epicardial adipose tissue for screening coronary atherosclerosis.Heart and vessels · 2025Article
- Prevalence of diffuse idiopathic skeletal hyperostosis and association with coronary artery calcifications in Slovenia.Radiology and oncology · 2025Article
- Coronary artery calcifications are not associated with epicardial adipose tissue volume and attenuation on computed tomography in 1,945 individuals with various degrees of glucose disorders.International journal of cardiology. Heart & vasculature · 2025Article
- Correlation analysis between epicardial adipose tissue and acute coronary syndrome.Scientific reports · 2025Article
- Radiomics parameters of epicardial adipose tissue predict mortality in acute pulmonary embolism.Respiratory research · 2024Article
- Exploring the relationship between epicardial fat and coronary plaque burden and characteristics: insights from cardiac ct imaging.The international journal of cardiovascular imaging · 2024Article
- Epicardial adipose tissue dispersion at CT and recurrent atrial fibrillation after pulmonary vein isolation.European radiology · 2024Article
- Quality of epicardial adipose tissue predicts major adverse cerebral and cardiovascular events following transcatheter aortic valve implantation.Heart and vessels · 2024Article
- Deep learning-based workflow for automatic extraction of atria and epicardial adipose tissue on cardiac computed tomography in atrial fibrillation.Journal of the Chinese Medical Association : JCMA · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveEpicardial adipose tissue (EAT) volume is associated with coronary plaque burden and adverse events. We aimed to determine, whether CT-derived EAT attenuation in addition to EAT volume distinguishes patients with and without myocardial infarction. METHODS AND
resultsIn 94 patients with confirmed or suspected coronary artery disease (aged 66.9±14.7years, 61%male) undergoing cardiac CT imaging as part of clinical workup, EAT volume was retrospectively quantified from non-contrast cardiac CT by delineation of the pericardium in axial images. Mean attenuation of all pixels from EAT volume was calculated. Patients with type-I myocardial infarction (n = 28) had higher EAT volume (132.9 ± 111.9ml vs. 109.7 ± 94.6ml, p = 0.07) and CT-attenuation (-86.8 ± 5.8HU vs. -89.0 ± 3.7HU, p = 0.03) than patients without type-I myocardial infarction, while EAT volume and attenuation were only modestly inversely correlated (r = -0.24, p = 0.02). EAT volume increased per standard deviation of age (18.2 [6.2-30.2] ml, p = 0.003), BMI (29.3 [18.4-40.2] ml, p<0.0001), and with presence of diabetes (44.5 [16.7-72.3] ml, p = 0.0002), while attenuation was higher in patients with lipid-lowering therapy (2.34 [0.08-4.61] HU, p = 0.04). In a model containing volume and attenuation, both measures of EAT were independently associated with the occurrence of type-I myocardial infarction (OR [95% CI]: 1.79 [1.10-2.94], p = 0.02 for volume, 2.04 [1.18-3.53], p = 0.01 for attenuation). Effect sizes remained stable for EAT attenuation after adjustment for risk factors (1.44 [0.77-2.68], p = 0.26 for volume; 1.93 [1.11-3.39], p = 0.02 for attenuation).
conclusionCT-derived EAT attenuation, in addition to volume, distinguishes patients with vs. without myocardial infarction and is increased in patients with lipid-lowering therapy. Our results suggest that assessment of EAT attenuation could render complementary information to EAT volume regarding coronary risk burden.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.