Evidence map›Paper›PMID 28839004›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2017

Ventilation and neurochemical changes during µ-opioid receptor activation or blockade of excitatory receptors in the hypoglossal motor nucleus of goats.

Thomas M Langer, Suzanne E Neumueller, Emma Crumley, Nicholas J Burgraff, Sawan Talwar, Matthew R Hodges, Lawrence Pan, Hubert V Forster

Open access · bronzeAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Opioids and obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Review
  3. Dynamic Rhythmogenic Network States Drive Differential Opioid Responses in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thomas M LangerDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Suzanne E NeumuellerDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Emma CrumleyDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Nicholas J BurgraffDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Sawan TalwarDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Matthew R HodgesDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Lawrence PanDepartment of Physical Therapy, Marquette University , Milwaukee, Wisconsin.
Hubert V ForsterDepartment of Physiology, Medical College of Wisconsin , Milwaukee, Wisconsin.
Medical College of Wisconsin · USMarquette University · US

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorderR01HL122358 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HODGES, MATTHEW ROBERT · 2015 to 2024
$4.3M
Interdependence among neuromodulators of ventilatory controlR01HL112996 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI FORSTER, HUBERT V · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL112996NHLBI NIH HHS R01 HL122358NHLBI NIH HHS T32 HL007852
6 · The paper itself

Abstract

Neuromodulator interdependence posits that changes in one or more neuromodulators are compensated by changes in other modulators to maintain stability in the respiratory control network. Herein, we studied compensatory neuromodulation in the hypoglossal motor nucleus (HMN) after chronic implantation of microtubules unilaterally ( n = 5) or bilaterally ( n = 5) into the HMN. After recovery, receptor agonists or antagonists in mock cerebrospinal fluid (mCSF) were dialyzed during the awake and non-rapid eye movement (NREM) sleep states. During day studies, dialysis of the µ-opioid inhibitory receptor agonist [d-Ala

Indexed as

RespirationAnimalsAtropineElectromyographyEnkephalin, Ala(2)-MePhe(4)-Gly(5)-FemaleGoatsMedulla OblongataMuscarinic AntagonistsReceptors, Opioid, muSerotoninSleepWakefulnessAtropineEnkephalin, Ala(2)-MePhe(4)-Gly(5)-Muscarinic AntagonistsReceptors, Opioid, muSerotoninbreathinghypoglossal motor nucleusneuromodulationopioids

Identifiers

PMID28839004
PMCPMC5814683
OpenAlexW2747278778

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.