Evidence map›Paper›PMID 28842484›Full record

ArticleThe Journal of biological chemistry2017

Single-domain antibodies pinpoint potential targets within

Michael L Barta, Jonathan P Shearer, Olivia Arizmendi, Jacqueline M Tremblay, Nurjahan Mehzabeen, Qi Zheng, Kevin P Battaile, Scott Lovell, Saul Tzipori, William D Picking and 2 more

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Multifunctional antibody responses from a primateScience translational medicine · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Protective Effect of Nanobodies Targeting Sip Protein AgainstAnimals : an open access journal from MDPI · 2025
    Article
  6. Targeting Type III Secretion System usingIndian journal of microbiology · 2025
    Review
  7. Article
  8. Mapping the functional B-cell epitopes ofApplied and environmental microbiology · 2024
    Article
  9. Review
  10. Functional assays to evaluate antibody-mediated responses againstFrontiers in cellular and infection microbiology · 2023
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. TheMicroorganisms · 2021
    Review
  16. Composition and Biophysical Properties of the Sorting Platform Pods in theFrontiers in cellular and infection microbiology · 2021
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael L BartaFrom the Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047.
Jonathan P ShearerDepartment of Infectious Diseases and Global Health, Tufts Clinical and Translational Science Institute, North Grafton, Massachusetts 02111.
Olivia ArizmendiFrom the Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047.
Jacqueline M TremblayDepartment of Infectious Diseases and Global Health, Tufts Clinical and Translational Science Institute, North Grafton, Massachusetts 02111.
Nurjahan MehzabeenProtein Structure Laboratory, Del Shankel Structural Biology Center, University of Kansas, Lawrence, Kansas 66047, and.
Qi ZhengFrom the Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047.
Kevin P BattaileIMCA-CAT, Hauptman-Woodward Medical Research Institute, Argonne, Illinois 60439.
Scott LovellProtein Structure Laboratory, Del Shankel Structural Biology Center, University of Kansas, Lawrence, Kansas 66047, and.
Saul TziporiDepartment of Infectious Diseases and Global Health, Tufts Clinical and Translational Science Institute, North Grafton, Massachusetts 02111.
William D PickingFrom the Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047.
Charles B ShoemakerDepartment of Infectious Diseases and Global Health, Tufts Clinical and Translational Science Institute, North Grafton, Massachusetts 02111.
Wendy L PickingFrom the Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, wendy.picking@ku.edu.

Funding

Protein Structure Laboratory P30GM110761 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 2014 to 2018
$5.6M
The multiple states of IpaB Shigella type III secretionR01AI099489 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI PICKING, WILLIAM D. · 2013 to 2017
$2.2M
NIAID NIH HHS R01 AI099489NIGMS NIH HHS P30 GM110761
6 · The paper itself

Abstract

Numerous Gram-negative pathogens infect eukaryotes and use the type III secretion system (T3SS) to deliver effector proteins into host cells. One important T3SS feature is an extracellular needle with an associated tip complex responsible for assembly of a pore-forming translocon in the host cell membrane.

Indexed as

AnimalsAntigens, BacterialBacterial ProteinsBacterial Secretion SystemsCamelids, New WorldDirected Molecular EvolutionEpitopesShigella flexneriSingle-Chain AntibodiesAntigens, BacterialBacterial ProteinsBacterial Secretion SystemsEpitopesIpaD protein, Shigella flexneriSingle-Chain Antibodiescrystal structureIpaDmicrobial pathogenesisShigellasingle-domain antibody (sdAb, nanobody)type III secretion system (T3SS)virulence factor

Identifiers

PMID28842484
PMCPMC5633129

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.