Evidence map›Paper›PMID 28856933›Full record

ArticleThe Journal of international medical research2018

Serum long noncoding RNA urothelial carcinoma-associated 1: A novel biomarker for diagnosis and prognosis of hepatocellular carcinoma.

Zhi-Kun Zheng, Cui Pang, Yang Yang, Qiong Duan, Ju Zhang, Wen-Chao Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Combinatorial Gene Expression Profiling of SerumInternational journal of molecular sciences · 2024
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  20. Genetic Polymorphisms of lncRNAInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhi-Kun Zheng1 Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Cui Pang1 Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Yang Yang1 Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Qiong Duan1 Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Ju Zhang2 Institute of Gene Diagnosis, School of Pharmacology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Wen-Chao Liu1 Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective Long noncoding RNAs (lncRNAs) offer great potential as cancer biomarkers. This study was performed to assess the applicability of serum lncRNA urothelial carcinoma-associated 1 (UCA1) as a diagnostic and/or prognostic biomarker for hepatocellular carcinoma (HCC). Methods We examined UCA1 expression in serum samples from 105 patients with HCC, 105 patients with benign liver disease (BLD), and 105 healthy volunteers using reverse-transcription polymerase chain reaction and analyzed the relationship between serum UCA1 and clinicopathological parameters of HCC as well as survival. Results Expression of serum UCA1 was significantly higher in patients with HCC and allowed for discrimination of HCC from BLD and healthy controls. High expression of serum UCA1 was significantly associated with a high tumor grade, large tumor size, positive vascular invasion, and advanced TNM stage. Multivariate analysis revealed that a high serum UCA1 level was an independent unfavorable prognostic factor for HCC. Conclusions Our results confirm the upregulation of serum UCA1 expression in HCC and indicate its clinical value as a noninvasive biomarker for HCC screening and prognostic prediction.

Indexed as

Gene Expression Regulation, NeoplasticAgedBiomarkers, TumorCarcinoma, HepatocellularCase-Control StudiesDiagnosis, DifferentialFemaleHepatitisHumansLiver NeoplasmsMaleMiddle AgedNeoplasm GradingNeoplasm StagingPrognosisRNA, Long NoncodingBiomarkers, TumorRNA, Long NoncodingUCA1 RNA, humanbiomarkersdiagnosishepatocellular carcinomaLncRNAspolymerase chain reactionUCA1

Identifiers

PMID28856933
PMCPMC6011314

What Socratic holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.