Trial reportJournal of the American Geriatrics Society2017
High Symptom Burden and Low Functional Status in the Setting of Multimorbidity.
Trial report in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It reports registered trial NCT01415934. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multisite Randomized Controlled Trial of Continuing vs. Discontinuing Statins
Open the trial in the graphWho cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- General practitioner strategies for managing patients with multimorbidity: a systematic review and thematic synthesis of qualitative research.BMC family practice · 2020Pooled it
- Article
- Symptom burden in multiple long-term conditions: An AI-supported, mixed-methods concept elicitation study.JRSM open · 2026Article
- Distinct Symptom Profiles in Younger and Older Patients With Cancer Receiving Chemotherapy.Cancer medicine · 2026Article
- Autonomic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Findings from the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study in the USA.Journal of clinical medicine · 2025Article
- Multimorbidity Management: A Scoping Review of Interventions and Health Outcomes.International journal of environmental research and public health · 2025Article
- Prognostic impact of patient-reported symptoms in multiple myeloma.Blood advances · 2025Article
- Symptom representations in people with multimorbidity undergoing treatment for cancer: a qualitative descriptive study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Cross-cultural adaptation and validation of the caregiver self-efficacy in contributing to patient self-care scale in China.BMC public health · 2024Article
- Living with multimorbidity: A qualitative exploration of shared experiences of patients, family caregivers, and healthcare professionals in managing symptoms in the United States.Journal of advanced nursing · 2024Article
- Association of Functional Status and Symptom Severity Among Patients Who Received Palliative Care Consultations.Journal of palliative medicine · 2024Article
- Common and distinct risk factors that influence more severe and distressing shortness of breath profiles in oncology outpatients.Cancer medicine · 2024Article
- Interventions Addressing Symptoms in Older Adults with Multimorbidity: An Umbrella Review.Journal of multidisciplinary healthcare · 2024Review
- Functional Status Changes in Patients Receiving Palliative Care Consult During COVID-19 Pandemic.Journal of pain and symptom management · 2023Article
- Identification of distinct symptom profiles in patients with gynecologic cancers using a pre-specified symptom cluster.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Simultaneous exercise stress cardiac magnetic resonance and cardiopulmonary exercise testing to elucidate the Fick components of aerobic exercise capacity: a feasibility and reproducibility study and pilot study in hematologic cancer survivors.Cardio-oncology (London, England) · 2023Article
- The Experiences and Views on Palliative Care of Older People with Multimorbidities, Their Family Caregivers and Professionals in a Spanish Hospital.Healthcare (Basel, Switzerland) · 2022Article
- Self-reported symptom causes of mobility difficulty contributing to fear of falling in older adults.Aging clinical and experimental research · 2022Article
- The Effect of Dual Sensory Impairment and Multimorbidity Patterns on Functional Impairment: A Longitudinal Cohort of Middle-Aged and Older Adults in China.Frontiers in aging neuroscience · 2022Article
- SymTrak-8 as a Brief Measure for Assessing Symptoms in Older Adults.Journal of general internal medicine · 2021Article
Corrections and comments
- Erratum issuedCorrigendum.2019
Authors and funding
4 authors.
Funding
Abstract
objectivesTo enhance understanding of the relationship between multimorbidity, symptom burden, and functional status in individuals with life-limiting illness.
designSecondary analysis of baseline data from a randomized clinical trial conducted in the Palliative Care Research Cooperative Group. Group differences were tested using a t-test; multivariate regression analysis was used to determine the effect of multiple variables on functional status and symptom burden.
settingFifteen Palliative Care Research Cooperation sites.
participantsAdults who participated in a parent statin-discontinuation clinical trial were included in the analysis (N = 381). Inclusion criteria were diagnosis of a life-limiting illness, statin use for 3 months or longer, life expectancy longer than 1 month, and declining functional status. MEASUREMENTS: Cancer diagnosis (solid organ and hematologic malignancies), multimorbidity (Charlson Comorbidity Index (CCI) score), symptom burden (Edmonton Symptom Assessment Scale (ESAS) score, number of symptoms with ESAS severity score >4), functional status (Australia-modified Karnofsky Performance Scale (AKPS)).
resultsFifty-one percent had a primary diagnosis of cancer; mean age 74.1 ± 11.6. Participants had multiple comorbid illnesses (CCI score 4.9 ± 2.8), multiple symptoms (ESAS score 27.2 ± 15.9), and poor functional status (AKPS = 53 ± 13). In univariate and multivariate analyses, multimorbidity was associated with greater symptom burden (4.2 vs 3.1 moderate or severe symptoms (t = -3.2, P = .002), 12% vs 6% with severe symptoms (t = -3.7, P < .001)), but cancer diagnosis was not. In univariate and multivariate analyses, higher symptom burden was associated with poorer functional status (F = 11.6, P < .001), but multimorbidity was not.
conclusionSymptoms cannot be attributed solely to a diagnosis of cancer. The association between symptom burden and functional status underscores the importance of clinical attention to symptoms in individuals with multimorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.