Trial reportDiabetes2017
Opioid Receptor Activation Impairs Hypoglycemic Counterregulation in Humans.
Trial report in Diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review.Diabetologia · 2022Pooled it
- Effects of Intranasal Naloxone on Hypoglycemia-associated Autonomic Failure in Susceptible Individuals.The Journal of clinical endocrinology and metabolism · 2025Trial
- Insulinoma Mimic: Tramadol-induced Hypoglycemia.JCEM case reports · 2025Article
- The Impact of Patient-Controlled Analgesia Combined with Self-Management Training on Pain Modulation in Diabetic Patients with Chronic Knee Pain.Journal of pain research · 2025Article
- Current and future therapies to treat impaired awareness of hypoglycemia.Frontiers in pharmacology · 2023Review
- Nutritional status and eating habits of people who use drugs and/or are undergoing treatment for recovery: a narrative review.Nutrition reviews · 2021Review
- Plasma Epinephrine Contributes to the Development of Experimental Hypoglycemia-Associated Autonomic Failure.The Journal of clinical endocrinology and metabolism · 2020Article
- Hypoglycemic risk exposures in relation to low serum glucose values in ambulatory patients.Medicine · 2020Observational
- Effect of beta blocker use and type on hypoglycemia risk among hospitalized insulin requiring patients.Cardiovascular diabetology · 2019Article
- Potential approaches to prevent hypoglycemia-associated autonomic failure.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Although intensive glycemic control improves outcomes in type 1 diabetes mellitus (T1DM), iatrogenic hypoglycemia limits its attainment. Recurrent and/or antecedent hypoglycemia causes blunting of protective counterregulatory responses, known as hypoglycemia-associated autonomic failure (HAAF). To determine whether and how opioid receptor activation induces HAAF in humans, 12 healthy subjects without diabetes (7 men, age 32.3 ± 2.2 years, BMI 25.1 ± 1.0 kg/m
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.