Observational studyJournal of the American Heart Association2017
Prevalence and Characteristics of Carotid Artery High-Risk Atherosclerotic Plaques in Chinese Patients With Cerebrovascular Symptoms: A Chinese Atherosclerosis Risk Evaluation II Study.
Observational study in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02017756 (A Phase II Study of Chinese Atherosclerosis Risk Evaluation), which is not on this map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase II Study of Chinese Atherosclerosis Risk Evaluation: Investigation of Carotid Atherosclerotic Disease in Patients With Ischemic Cerebrovascular Events
Who cites it
54 citing papers in PubMed, 98 citations in OpenAlex.
- Identification of high-risk carotid plaque with MRI-based radiomics and machine learning.European radiology · 2021Trial
- Carotid plaque vulnerability and circle of Willis anatomy predict ipsilateral brain infarcts and long-term mortality in carotid endarterectomy patients.GeroScience · 2026Article
- Non-stenotic Carotid Disease: Review of the Literature and Case Discussion of TCAR for Treatment.Seminars in neurology · 2026Review
- Computed Tomography Angiography "Rim Sign" for Detecting Carotid Intraplaque Hemorrhage: A Computed Tomography Angiography-Magnetic Resonance Imaging-Histology Correlation Study.Journal of the American Heart Association · 2026Article
- Machine Learning Applied to CT Radiomics Identifies Symptomatic Carotid Plaques.Current medical imaging · 2026Article
- The Correlation between Inflammatory Markers and Carotid Atherosclerotic Plaque Characteristics.Cerebrovascular diseases extra · 2026Article
- Metabolically Abnormal Obesity and Carotid Plaque Vulnerability: A Vessel Wall MRI Study Linking Obesity Phenotypes to Atherosclerotic Instability.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Carotid atherosclerotic plaque vulnerability assessment from angiography-derived radial wall strain validated by MRI.Scientific reports · 2025Article
- Carotid Plaque Characteristics Combined With Serum Inflammatory Biomarkers Predict Recurrent Ischemic Stroke.Brain and behavior · 2025Article
- Carotid artery segmentation in computed tomography angiography (CTA) using multi-scale deep supervision with Swin-UNet and advanced data augmentation.Quantitative imaging in medicine and surgery · 2025Article
- The value of contrast-enhanced ultrasound in assessing carotid plaque vulnerability and predicting stroke risk.Scientific reports · 2025Article
- Risk prediction of recurrent ischemic stroke based on Carotid Plaque-RADS: construction and validation of a nomogram model.Frontiers in aging neuroscience · 2025Article
- Robustness and classification capabilities of MRI radiomic features in identifying carotid plaque vulnerability.The British journal of radiology · 2024Article
- Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC.European heart journal · 2024Article
- Findings of Angiography and Carotid Vessel Wall Imaging Associated with Post-Procedural Clinical Events after Carotid Artery Stenting.Neurointervention · 2024Article
- Quantifying Carotid Stenosis: History, Current Applications, Limitations, and Potential: How Imaging Is Changing the Scenario.Life (Basel, Switzerland) · 2024Review
- Explore the value of carotid ultrasound radiomics nomogram in predicting ischemic stroke risk in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2024Article
- Histological validation of three-dimensional variable flip angle turbo spin echo multi-contrast magnetic resonance vessel wall imaging in characterizing carotid vulnerable atherosclerotic plaques.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Heavy macrophage infiltration identified by optical coherence tomography relates to plaque rupture.Annals of clinical and translational neurology · 2023Article
- Haemodynamic Effects on the Development and Stability of Atherosclerotic Plaques in Arterial Blood Vessel.Interdisciplinary sciences, computational life sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarotid atherosclerotic plaque rupture is an important source of ischemic stroke. However, the prevalence of high-risk plaque (HRP) defined as plaques with luminal surface disruption, a lipid-rich necrotic core occupying >40% of the wall, or intraplaque hemorrhage in Chinese population remains unclear. This study uses carotid magnetic resonance imaging (CMRI) to investigate HRP prevalence in carotid arteries of Chinese patients with cerebrovascular symptoms. METHODS AND
resultsPatients with cerebral ischemic symptoms in the anterior circulation within 2 weeks and carotid plaque determined by ultrasound were recruited and underwent CMRI. The HRP features were identified and compared between symptomatic and asymptomatic arteries. Receiver-operating-characteristic analysis was used to calculate area-under-the-curve (AUC) of stenosis and maximum wall thickness for discriminating presence of HRP. In 1047 recruited subjects, HRP detected by CMRI was nearly 1.5 times more prevalent than severe stenosis (≥50%) in this cohort (28% versus 19%,
conclusionsThere are significantly more high-risk carotid plaques than carotid arteries with ≥50% stenosis in symptomatic Chinese patients. A substantial number of HRPs were found in arteries with lower grade stenosis and maximum wall thickness was a stronger indicator for HRP than luminal stenosis. CLINICAL
trial registrationURL: https://www.clinicaltrials.gov/. Unique identifier: NCT02017756.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.