Evidence map›Paper›PMID 28864471›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells.

Trevor Smith, Xiaotian Lin, Marielle Mello, Kristi Marquardt, Jocelyn Cheung, Binfeng Lu, Linda A Sherman, Grégory Verdeil

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Research advances in the role of MAPK cascade in regulation of cell growth, immunity, inflammation, and cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Trevor SmithDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037.
Xiaotian LinDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0002-9938-7633
Marielle MelloCentre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, CNRS, INSERM, 13009 Marseille, France.ORCID 0000-0002-5454-3559
Kristi MarquardtDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037.
Jocelyn CheungDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037.
Binfeng LuDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; and.
Linda A ShermanDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037.ORCID 0000-0001-6422-7069
Grégory VerdeilDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037; gregory.verdeil@unil.ch.ORCID 0000-0001-9445-8474
Scripps Research Institute · USInserm · FRUniversity of Pittsburgh · US

Funding

THYMIC AND PERIPHERAL CD8+ T CELL TOLERANCER01DK050824 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI SHERMAN, LINDA A · 1995 to 2014
$5.0M
NIDDK NIH HHS R01 DK050824
6 · The paper itself

Abstract

Peripheral tolerance mechanisms exist to prevent autoimmune destruction by self-reactive T cells that escape thymic deletion. Dominant tolerance imposed by CD4

Indexed as

Clonal DeletionPeripheral ToleranceAnimalsCD11c AntigenCD8-Positive T-LymphocytesCell LineCross-PrimingDendritic CellsLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMice, Transgenicp38 Mitogen-Activated Protein KinasesReceptors, Antigen, T-CellSignal TransductionCD11c Antigenp38 Mitogen-Activated Protein KinasesReceptors, Antigen, T-Cell

Identifiers

PMID28864471
PMCPMC5679299
OpenAlexW2751632785

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.