Evidence map›Paper›PMID 28869601›Full record

ReviewOncogene2018

Role of SMAD proteins in colitis-associated cancer: from known to the unknown.

P Chandrasinghe, B Cereser, M Moorghen, I Al Bakir, N Tabassum, A Hart, J Stebbing, J Warusavitarne

Abstract readReview
PubMed Publisher
In one paragraph

Review in Oncogene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Inflammatory bowel disease and carcinogenesis.Cancer metastasis reviews · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. 1,25(OH)Cell cycle (Georgetown, Tex.) · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

P ChandrasingheDepartment of Surgery and Cancer, Imperial College London, London, UK.
B CereserDepartment of Surgery and Cancer, Imperial College London, London, UK.
M MoorghenSt. Mark's Hospital, London, Harrow, UK.
I Al BakirSt. Mark's Hospital, London, Harrow, UK.
N TabassumDepartment of Surgery and Cancer, Imperial College London, London, UK.
A HartDepartment of Surgery and Cancer, Imperial College London, London, UK.
J StebbingDepartment of Surgery and Cancer, Imperial College London, London, UK.
J WarusavitarneDepartment of Surgery and Cancer, Imperial College London, London, UK.
Imperial College London · GBQueen Mary University of London · GBSt Mark's Hospital · GBUniversity of Kelaniya · LK

Funding

Department of Health NIHR-RP-011-053Medical Research Council MR/P00122X/1
6 · The paper itself

Abstract

Small mothers against decapentaplegic (SMAD) proteins are a family of signal transduction molecules in transforming growth factor β (TGFβ) ligand pathways that have been found to have a key role in the pathogenesis of inflammatory bowel disease (IBD). Long standing IBD predisposes individuals to colitis-associated colorectal cancer (CAC), an entity that possess unique characteristics compared to hereditary and sporadic cancer. The ligands of the TGFβ super family along with SMADs have also been implicated in several aspects of colorectal cancer formation. SMAD proteins are shown to be involved in a number of potentially carcinogenic mechanisms such as altering gene transcription, controlling stem cell differentiation to causing epigenetic changes. Modulation of these proteins has emerged as a novel therapeutic intervention for IBD although its effect on carcinogenesis remains elusive. This account reviews available evidence linking SMAD proteins to CAC and explores the potential areas for future research in this area.

Indexed as

AnimalsCarcinogenesisCell DifferentiationCell ProliferationColorectal NeoplasmsHumansInflammatory Bowel DiseasesPhosphorylationSignal TransductionSmad ProteinsTransforming Growth Factor betaSmad ProteinsTransforming Growth Factor beta

Identifiers

PMID28869601
OpenAlexW2750974859

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.