Evidence map›Paper›PMID 28870631›Full record

ReviewAtherosclerosis2017

The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis.

Bożena Sosnowska, Mohsen Mazidi, Peter Penson, Anna Gluba-Brzózka, Jacek Rysz, Maciej Banach

Registry-linked trialOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Atherosclerosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT03393377. Cited by 92 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 5 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03393377 nacompleted

Preventive Arterial Wall Phenotype in Subjects at Moderate Cardiovascular Risk Induced by Very Low-dose Fluvastatin/Valsartan Combination: a Pilot Study

Ran2014Enrolled20Registered outcomes19Posted comparisons0ConditionsAtherosclerosisArmsfluvastatin 10 mg and valsartan 20 mg, Placebo
PMID 27040132PMID 28012835PMID 22385885PMID 20338492PMID 24263076PMID 27222591PMID 28408026PMID 26567372PMID 24814489other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 5 syntheses or guidelines pooled it, 185 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. SIRT3-Mediated Deacetylation of DRP1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Bożena SosnowskaDepartment of Hypertension, Medical University of Lodz, Lodz, Poland.
Mohsen MazidiKey State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Peter PensonSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK. Electronic address: P.Penson@ljmu.ac.uk.
Anna Gluba-BrzózkaDepartment of Nephrology, Hypertension and Family Medicine, WAM University Hospital, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
Jacek RyszDepartment of Nephrology, Hypertension and Family Medicine, WAM University Hospital, Lodz, Poland.
Maciej BanachDepartment of Hypertension, Medical University of Lodz, Lodz, Poland; Polish Mother's Memorial Hospital Research Institute, Lodz, Poland; Cardiovascular Research Centre, University of Zielona-Gora, Zielona-Gora, Poland. Electronic address: maciejbanach77@gmail.com.
Medical University of Lodz · PLChinese Academy of Sciences · CNLiverpool John Moores University · GBPolish Mother’s Memorial Hospital Research Institute · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sirtuins, silent mating-type information regulation 2 (SIRTs), are a family of nicotinamide adenine dinucleotide (NAD

Indexed as

AtherosclerosisBlood VesselsHumansSirtuin 1Sirtuin 3SirtuinsSIRT1 protein, humanSIRT3 protein, humanSIRT6 protein, humanSirtuin 1Sirtuin 3SirtuinsAtherosclerosisCVDLipid metabolismOxidative stressSIRT1SIRT3SIRT6Sirtuin

Identifiers

PMID28870631
OpenAlexW2748577840

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.