ReviewInternational journal of molecular sciences2017
Comparative Response of Brain to Chronic Hypoxia and Hyperoxia.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- A Meta-Analysis of Multidimensional Cognitive Functions Changes in Different Intensities of High-Altitude Hypoxia.Brain and behavior · 2025Pooled it
- Fetal brain development in fetal growth restriction using MRI: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings.BMC infectious diseases · 2021Pooled it
- Oxidative Stress Markers to Investigate the Effects of Hyperoxia in Anesthesia.International journal of molecular sciences · 2019Trial
- Peripheral Oxygen Saturation Targets and Hyperoxemia in Critical Care: Influence of pH, FAntioxidants (Basel, Switzerland) · 2026Article
- Integration of transcriptomics and metabolomics to study the mechanism of Siwei Huangqi powder in Tibetan medicine for protecting against high-altitude hypoxic brain injuries.Journal of traditional and complementary medicine · 2025Article
- Inhibition of the HMGB1-RAGE Axis Attenuates Microglial Inflammation and Ameliorates Hypoxia-Induced Cognitive Impairment.International journal of molecular sciences · 2025Article
- Fetal MRI study of brain differences in early-onset fetal growth restriction versus healthy controls at 30 weeks of gestation.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Association of pulmonary function with the risk of incident Alzheimer's disease: a prospective cohort and Mendelian randomization study.Aging clinical and experimental research · 2025Article
- HIF-1α Pathway in COVID-19: A Scoping Review of Its Modulation and Related Treatments.International journal of molecular sciences · 2025Article
- The Effect of Ethanolic Extract of Brazilian Green Propolis and Artepillin C on Cytokine Secretion by Stage IV Glioma Cells Under Hypoxic and Normoxic Conditions.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Opinion: exploring alternative pathways to neuroprotection-nicotine and carbon monoxide as antioxidative factors in neurodegeneration and delirium.Frontiers in neurology · 2025Article
- A diffusion tensor imaging-based multidimensional study of brain structural changes after long-term high-altitude exposure and their relationships with cognitive function.Frontiers in physiology · 2024Article
- Association between SpOFrontiers in neurology · 2024Article
- Pulmonary Function Trajectories Preceding Death Among Older Adults: A Long-Term Community-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- [Perioperative hyperoxia-More harmful than beneficial?]Die Anaesthesiologie · 2023Review
- Redox Imbalance in Neurological Disorders in Adults and Children.Antioxidants (Basel, Switzerland) · 2023Review
- Association between transcutaneous oxygen saturation within 24 h of admission and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage: a retrospective analysis of the MIMIC-IV database.Frontiers in neurology · 2023Article
- Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs.Frontiers in veterinary science · 2023Article
- Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure.Frontiers in physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two antithetic terms, hypoxia and hyperoxia, i.e., insufficient and excess oxygen availability with respect to needs, are thought to trigger opposite responses in cells and tissues. This review aims at summarizing the molecular and cellular mechanisms underlying hypoxia and hyperoxia in brain and cerebral tissue, a context that may prove to be useful for characterizing not only several clinically relevant aspects, but also aspects related to the evolution of oxygen transport and use by the tissues. While the response to acute hypoxia/hyperoxia presumably recruits only a minor portion of the potentially involved cell machinery, focusing into chronic conditions, instead, enables to take into consideration a wider range of potential responses to oxygen-linked stress, spanning from metabolic to genic. We will examine how various brain subsystems, including energetic metabolism, oxygen sensing, recruitment of pro-survival pathways as protein kinase B (Akt), mitogen-activated protein kinases (MAPK), neurotrophins (BDNF), erythropoietin (Epo) and its receptors (EpoR), neuroglobin (Ngb), nitric oxide (NO), carbon monoxide (CO), deal with chronic hypoxia and hyperoxia to end-up with the final outcomes, oxidative stress and brain damage. A more complex than expected pattern results, which emphasizes the delicate balance between the severity of the stress imposed by hypoxia and hyperoxia and the recruitment of molecular and cellular defense patterns. While for certain functions the expectation that hypoxia and hyperoxia should cause opposite responses is actually met, for others it is not, and both emerge as dangerous treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.