ArticleJournal of experimental psychology. General2017
Threat of shock and aversive inhibition: Induced anxiety modulates Pavlovian-instrumental interactions.
Article in Journal of experimental psychology. General, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Overlapping Neurobiology of Induced and Pathological Anxiety: A Meta-Analysis of Functional Neural Activation.The American journal of psychiatry · 2021Pooled it
- Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related disorders.Molecular psychiatry · 2026Article
- Pavlovian bias is associated with symptom severity but not diagnostic status in individuals with both anxious and non-anxious depression.Translational psychiatry · 2025Article
- Article
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- Improving the Reliability of the Pavlovian Go/No-Go Task for Computational Psychiatry Research.Computational psychiatry (Cambridge, Mass.) · 2025Article
- Emotional, physiological, biochemical, and behavioral responses to acute stress and uncertainty in military personnel.PloS one · 2024Article
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Computational Mechanisms of Addiction and Anxiety: A Developmental Perspective.Biological psychiatry · 2023Review
- The Posterior Cingulate Cortex Reflects the Impact of Anxiety on Drift Rates During Cognitive Processing.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- The effects of induced positive and negative affect on Pavlovian-instrumental interactions.Cognition & emotion · 2022Article
- Obsessive-compulsive disorder is characterized by decreased Pavlovian influence on instrumental behavior.PLoS computational biology · 2022Article
- Freezing revisited: coordinated autonomic and central optimization of threat coping.Nature reviews. Neuroscience · 2022Review
- Threat of shock promotes passive avoidance, but not active avoidance.The European journal of neuroscience · 2022Article
- Aversive Pavlovian inhibition in adult attention-deficit/hyperactivity disorder and its restoration by mindfulness-based cognitive therapy.Frontiers in behavioral neuroscience · 2022Article
- Computational approaches and machine learning for individual-level treatment predictions.Psychopharmacology · 2021Review
- Linking Social Cognition to Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Pavlovian bias in Parkinson's disease: an objective marker of impulsivity that modulates with deep brain stimulation.Scientific reports · 2020Article
- Altered learning under uncertainty in unmedicated mood and anxiety disorders.Nature human behaviour · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Anxiety can be an adaptive response to potentially threatening situations. However, if experienced in inappropriate contexts, it can also lead to pathological and maladaptive anxiety disorders. Experimentally, anxiety can be induced in healthy individuals using the threat of shock (ToS) paradigm. Accumulating work with this paradigm suggests that anxiety promotes harm-avoidant mechanisms through enhanced inhibitory control. However, the specific cognitive mechanisms underlying anxiety-linked inhibitory control are unclear. Critically, behavioral inhibition can arise from at least 2 interacting valuation systems: instrumental (a goal-directed system) and Pavlovian (a "hardwired" reflexive system). The present study (N = 62) replicated a study showing improved response inhibition under ToS in healthy participants, and additionally examined the impact of ToS on aversive and appetitive Pavlovian-instrumental interactions in a reinforced go/no-go task. When Pavlovian and instrumental systems were in conflict, ToS increased inhibition to aversive events, while leaving appetitive interactions unperturbed. We argue that anxiety promotes avoidant behavior in potentially harmful situations by potentiating aversive Pavlovian reactions (i.e., promoting avoidance in the face of threats). Critically, such a mechanism would drive adaptive harm-avoidant behavior in threatening situations where Pavlovian and instrumental processes are aligned, but at the same time, result in maladaptive behaviors when misaligned and where instrumental control would be advantageous. This has important implications for our understanding of the mechanisms that underlie pathological anxiety. (PsycINFO Database Record
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.