ArticleJournal of food and drug analysis2015
Effect of storage time on metabolite profile and alpha-glucosidase inhibitory activity of Cosmos caudatus leaves - GCMS based metabolomics approach.
Article in Journal of food and drug analysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Season, storage and extraction method impact on the phytochemical profile of Terminalia ivorensis.BMC plant biology · 2023Article
- GC-MS- and NMR-Based Metabolomics and Molecular Docking Reveal the Potential Alpha-Glucosidase Inhibitors fromPharmaceuticals (Basel, Switzerland) · 2021Article
- Essential oil constituents and variations in antioxidant compounds of dried summer savory (Food science & nutrition · 2021Article
- AnFrontiers in pharmacology · 2021Article
- Variation in the metabolites and α-glucosidase inhibitory activity of Cosmos caudatus at different growth stages.BMC complementary and alternative medicine · 2019Article
- Antioxidants and α-glucosidase inhibitors from Neptunia oleracea fractions usingBMC complementary and alternative medicine · 2019Article
- Antioxidant Activities ofAntioxidants (Basel, Switzerland) · 2018Article
- Characterization of α-Glucosidase Inhibitors fromMolecules (Basel, Switzerland) · 2018Article
- Metabolite profiling, antioxidant, and α-glucosidase inhibitory activities of germinated rice: nuclear-magnetic-resonance-based metabolomics study.Journal of food and drug analysis · 2018Article
- Metabolic profiling investigation of Fritillaria thunbergii Miq. by gas chromatography-mass spectrometry.Journal of food and drug analysis · 2018Article
- Rapid characterization of metabolites in soybean using ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) and screening for α-glucosidase inhibitory and antioxidant properties through different solvent systems.Journal of food and drug analysis · 2018Article
- A comparative analysis for the volatile compounds of various Chinese dark teas using combinatory metabolomics and fungal solid-state fermentation.Journal of food and drug analysis · 2018Article
- Effect of storage temperature and time on the nutritional quality of walnut male inflorescences.Journal of food and drug analysis · 2017Article
- A comparative study of three tissue-cultured Dendrobium species and their wild correspondences by headspace gas chromatography-mass spectrometry combined with chemometric methods.Journal of food and drug analysis · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cosmos caudatus, which is a commonly consumed vegetable in Malaysia, is locally known as "Ulam Raja". It is a local Malaysian herb traditionally used as a food and medicinal herb to treat several maladies. Its bioactive or nutritional constituents consist of a wide range of metabolites, including glucosinolates, phenolics, amino acids, organic acids, and sugars. However, many of these metabolites are not stable and easily degraded or modified during storage. In order to investigate the metabolomics changes occurring during post-harvest storage, C. caudatus samples were subjected to seven different storage times (0 hours, 2 hours, 4 hours, 6 hours, 8 hours, 10 hours, and 12 hours) at room temperature. As the model experiment, the metabolites identified by gas chromatography-mass spectrometry (GC-MS) were correlated with α-glucosidase inhibitory activity analyzed with multivariate data analysis (MVDA) to find out the variation among samples and metabolites contributing to the activity. Orthogonal partial least squares (OPLS) analysis was applied to investigate the metabolomics changes. A profound chemical alteration, both in primary and secondary metabolites, was observed. The α-tocopherol, catechin, cyclohexen-1-carboxylic acid, benzoic acid, myo-inositol, stigmasterol, and lycopene compounds were found to be the discriminating metabolites at early storage; however, sugars such as sucrose, α-d-galactopyranose, and turanose were detected, which was attributed to the discriminating metabolites for late storage. The result shows that the MVDA method is a promising technique to identify biomarker compounds relative to storage at different times.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.