ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017
Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival.
Abstract read
In one paragraph
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Transcriptomic analysis identifies a potential target for bevacizumab resistant glioblastoma.Scientific reports · 2025Article
- Quercetin Increases Expression of Membrane-TRAIL in Glioblastoma Cells Resulting in Apoptosis.Cancers · 2025Article
- Article
- Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities.Journal of translational medicine · 2025Review
- Cellular Uptake of Bevacizumab in Cervical and Breast Cancer Cells Revealed by Single-Molecule Spectroscopy.The journal of physical chemistry letters · 2023Article
- Inhibition of Macropinocytosis Enhances the Sensitivity of Osteosarcoma Cells to Benzethonium Chloride.Cancers · 2023Article
- Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis.Nature communications · 2022Article
- Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma.International journal of molecular sciences · 2021Review
- A Key Pathway to Cancer Resilience: The Role of Autophagy in Glioblastomas.Frontiers in oncology · 2021Review
- Macropinocytosis: mechanism and targeted therapy in cancers.American journal of cancer research · 2021Review
- Update on Chemotherapeutic Approaches and Management of Bevacizumab Usage for Glioblastoma.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Curcumin attenuates bevacizumab-induced toxicity via suppressing oxidative stress and preventing mitochondrial dysfunction in heart mitochondria.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Single-Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2020Article
- Super selective intra-arterial cerebral infusion of modern chemotherapeutics after blood-brain barrier disruption: where are we now, and where we are going.Journal of neuro-oncology · 2020Review
- Tailored Lipoprotein-Like miRNA Delivery Nanostructure Suppresses Glioma Stemness and Drug Resistance through Receptor-Stimulated Macropinocytosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Epigenetic changes in fibroblasts drive cancer metabolism and differentiation.Endocrine-related cancer · 2019Review
- Role of endolysosomes and pH in the pathogenesis and treatment of glioblastoma.Cancer reports (Hoboken, N.J.) · 2019Article
- Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors.Oncotarget · 2018Review
- Shedding of bevacizumab in tumour cells-derived extracellular vesicles as a new therapeutic escape mechanism in glioblastoma.Molecular cancer · 2018Article
- An Interplay between Senescence, Apoptosis and Autophagy in Glioblastoma Multiforme-Role in Pathogenesis and Therapeutic Perspective.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Gaëlle Müller-GrevenDepartment of Cancer Biology, Cleveland Clinic, Cleveland, Ohio.
Cathleen R CarlinDepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio.
Monica E BurgettDepartment of Cancer Biology, Cleveland Clinic, Cleveland, Ohio.
Manmeet S AhluwaliaBrain Tumor and Neuro-Oncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
Adam LaukoDepartment of Cancer Biology, Cleveland Clinic, Cleveland, Ohio.
Amy S NowackiDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio.
Cameron J HertingDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Maha A QadanDepartment of Cancer Biology, Cleveland Clinic, Cleveland, Ohio.
Markus BredelDepartment of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama.
Steven A TomsDepartment of Neurosurgery, Geisinger Medical Center, Geisinger, Pennsylvania.
Justin D LathiaBrain Tumor and Neuro-Oncology Center, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
Dolores HambardzumyanDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Jann N SarkariaDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Petra HamerlikBrain Tumor Biology, Danish Cancer Society Research Center, Copenhagen, Denmark.
Candece L GladsonDepartment of Cancer Biology, Cleveland Clinic, Cleveland, Ohio. gladsoc@ccf.org.
Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MTargeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK · 2004 to 2015
$22.5MGraduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1MNon-neoplastic cell types dictate gliomagenesis andU01CA160882 · NCI · EMORY UNIVERSITY · PI HAMBARDZUMYAN, DOLORES, HOLLAND, ERIC C. · 2012 to 2016
$2.8MMechanisms Promoting Angiogenesis in GlioblastomaR01CA175120 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI GLADSON, CANDECE L · 2013 to 2017
$1.7MMechanisms of acquired temozolomide resistance in glioblastoma multiformeR01CA176830 · NCI · MAYO CLINIC ROCHESTER · PI SARKARIA, JANN N. · 2013 to 2017
$1.6MBrain Endothelial TNF-R1 Can Function to Inhibit AngiogenesisR01CA152883 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI GLADSON, CANDECE L · 2010 to 2014
$1.6MSpinning Disk Confocoal MicroscopeS10RR026820 · NCRR · CLEVELAND CLINIC LERNER COM-CWRU · PI DRAZBA, JUDY · 2010 to 2010
$500kNCI NIH HHS P30 CA013148NCI NIH HHS P50 CA108961NCI NIH HHS R01 CA152883NCI NIH HHS R01 CA175120NCI NIH HHS R01 CA176830NCI NIH HHS U01 CA160882NCRR NIH HHS S10 RR026820NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32 GM008602
Abstract
PubMed holds no abstract for this paper.
Indexed as
ActinsAnimalsAntineoplastic Agents, ImmunologicalAutophagyBevacizumabBiomarkersCell Line, TumorCell MembraneDisease Models, AnimalEndosomesGlioblastomaHumansImmunophenotypingLysosomesMiceNeovascularization, PathologicActinsAntineoplastic Agents, ImmunologicalBevacizumabBiomarkers
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.