Evidence map›Paper›PMID 28912780›Full record

ReviewFrontiers in immunology2017

Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases.

Ioana Mozos, Clemens Malainer, Jarosław Horbańczuk, Cristina Gug, Dana Stoian, Constantin Tudor Luca, Atanas G Atanasov

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 215 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed, 9 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04259606 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effect of Cassia Cinnamon on Arterial Stiffness Parameters in Patients With Type 2 Diabetes Mellitus

TypeinterventionalSponsorUniversity of GuadalajaraRan2018 to 2022Enrolled30ConditionsArterial StiffnessArmsCassia Cinnamon, Calcined magnesia
NCT05387174 nacompletednot on this mapstarted 2021, after this paper: background citation

Nursing Intervention in Two Risk Factors of the Metabolic Syndrome, Abdominal Obesity and Arterial Hypertension, and Quality of Life in the Climacteric Period

TypeinterventionalSponsorUniversidad de ConcepcionRan2021 to 2021Enrolled80ConditionsObesity, Abdominal, Hypertension, Quality of Life, MenopauseArms: Nursing intervention in two risk factors of the Metabolic Syndrome, abdominal obesity and arterial hypertension and quality of life in the climacteric period.
3 · Its place in the literature

Who cites it

215 citing papers in PubMed, 9 syntheses or guidelines pooled it, 354 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Arterial Stiffness in Inflammatory Bowel Disease: An Updated Systematic Review and Meta-Analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021
    Pooled it
  6. Cardiovascular Changes in Menopause.Current cardiology reviews · 2021
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
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  16. Article
  17. Review
  18. CD8Immunity & ageing : I & A · 2026
    Article
  19. Review
  20. Article

155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Ioana MozosDepartment of Functional Sciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Clemens MalainerIndependent Researcher, Vienna, Austria.
Jarosław HorbańczukThe Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, Poland.
Cristina GugDepartment of Microscopic Morphology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Dana Stoian2nd Department of Internal Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Constantin Tudor LucaDepartment of Cardiology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Atanas G AtanasovThe Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzębiec, Poland.
Victor Babeș University of Medicine and Pharmacy Timișoara · ROMedical University of Vienna · ATPolish Academy of Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies. Diverse studies revealed significant correlations between the severity of arterial stiffness and inflammatory markers, such as white blood cell count, neutrophil/lymphocyte ratio, adhesion molecules, fibrinogen, C-reactive protein, cytokines, microRNAs, and cyclooxygenase-2, in patients with a broad variety of diseases, such as metabolic syndrome, diabetes, coronary heart disease, peripheral arterial disease, malignant and rheumatic disorders, polycystic kidney disease, renal transplant, familial Mediterranean fever, and oral infections, and in women with preeclampsia or after menopause. There is strong evidence that inflammation plays an important and, at least, partly reversible role in the development of arterial stiffness, and inflammatory markers may be useful additional tools in the assessment of the cardiovascular risk in clinical practice. Combined assessment of arterial stiffness and inflammatory markers may improve non-invasive assessment of cardiovascular risk, enabling selection of high-risk patients for prophylactic treatment or more regular medical examination. Development of future destiffening therapies may target pro-inflammatory mechanisms.

Indexed as

arterial stiffnesscardiovascular diseasescardiovascular risk factorsinflammationinflammatory markers

Identifiers

PMID28912780
PMCPMC5583158
OpenAlexW2751105354

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.