Evidence map›Paper›PMID 28913467›Full record

ReviewRomanian journal of anaesthesia and intensive care2015

Duloxetine, an antidepressant with analgesic properties - a preliminary analysis.

Adela Hilda Onuţu

2 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Romanian journal of anaesthesia and intensive care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03792828 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

Pre-emptive Effect of Duloxetine in the Second Knee in Staged Total Knee Arthroplasty: A Randomized Controlled Study

TypeinterventionalSponsorSeoul National University HospitalRan2019 to 2019Enrolled90ConditionsKnee OsteoarthritisArmsDuloxetine HCl 30mg
NCT05311774 nacompletednot on this mapstarted 2022, after this paper: background citation

Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain

TypeinterventionalSponsorAssiut UniversityRan2022 to 2025Enrolled400ConditionsCancer PainArmsDuloxetine 30 mg, Tramadol, Placebo
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  12. Drug Repurposing: A Leading Strategy for New Threats and Targets.ACS pharmacology & translational science · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Adela Hilda OnuţuOrthopaedic and Trauma Clinic, Emergency County Hospital Cluj-Napoca, Romania.
Clinical Emergency Hospital Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serotonin and norepinephrine reuptake inhibitors are second-line antidepressants largely used because of their good tolerance and their reduced side effects. Two of these drugs, duloxetine and venlafaxine, are used also in chronic pain management. In this review we present recent data regarding duloxetine's effects on the central nervous system, linked to acute pain management, and their efficiency in reducing postoperative chronic pain. The drug's efficacy results from its modulating effect on the descending inhibitory pain pathways and the inhibition of the nociceptive input. There are already several studies in favor of the analgesic properties of duloxetine. However, further and larger randomized studies are necessary in order to clarify duloxetine efficiency in acute postoperative settings, and thereafter on persistent chronic postoperative pain.

Indexed as

acute postoperative painchronic post-surgical painduloxetineserotonin-norepinephrine reuptake inhibitors

Identifiers

PMID28913467
PMCPMC5505372
OpenAlexW3001157776

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.