Evidence map›Paper›PMID 28913588›Full record

SynthesisWorld journal of urology2017

Efficacy of PDE5Is and SSRIs in men with premature ejaculation: a new systematic review and five meta-analyses.

Yi Sun, Lu Yang, Yige Bao, Zhenhua Liu, Liangren Liu, Qiang Wei

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yi SunDepartment of Urology, West China Hospital of Sichuan University, No.37 Guoxue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
Lu YangDepartment of Urology, West China Hospital of Sichuan University, No.37 Guoxue Xiang, Chengdu, 610041, Sichuan, People's Republic of China. wycleflue@163.com.
Yige BaoDepartment of Urology, West China Hospital of Sichuan University, No.37 Guoxue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
Zhenhua LiuDepartment of Urology, West China Hospital of Sichuan University, No.37 Guoxue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
Liangren LiuDepartment of Urology, West China Hospital of Sichuan University, No.37 Guoxue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.
Qiang WeiDepartment of Urology, West China Hospital of Sichuan University, No.37 Guoxue Xiang, Chengdu, 610041, Sichuan, People's Republic of China. weiqiang933@126.com.ORCID http://orcid.org/0000-0003-3750-3042
Sichuan University · CN

Funding

National Natural Science Foundation of China 81200551National Natural Science Foundation of China 81370855National Natural Science Foundation of China (CN) 81300627Prostate Cancer Foundation Young Investigator Award 2013 and Foundation of Science &Technology Department of Sichuan Province 2013SZ0006Prostate Cancer Foundation Young Investigator Award 2013 and Foundation of Science &Technology Department of Sichuan Province 2013SZ0093Prostate Cancer Foundation Young Investigator Award 2013 and Foundation of Science &Technology Department of Sichuan Province 2015SZ0230Scientific Research Project of Health Department of Sichuan Province 120203
6 · The paper itself

Abstract

purposeTo clarify the efficacy of phosphodiesterase-5 inhibitors (PDE5Is) and selective serotonin reuptake inhibitors (SSRIs) in men with premature ejaculation (PE).

methodsWe searched the PubMed, Embase, and Cochrane Library databases to identify all randomized, controlled trials (RCTs) and compared the results, including intravaginal ejaculation latency time, satisfaction, intercourse per-week and side effects after treatment with PDE5I or SSRIs versus placebo, combined use of PDE5I with SSRIs versus PDE5I or SSRIs alone, and PDE5I versus SSRIs for treating PE.

resultsThe study inclusion criteria were met by 23 studies (ten RCTs with five crossover studies) involving 6145 patients. The data synthesized from these studies indicated that the efficacy of PDE5Is and SSRIs was better than that of placebo (p < 0.00001; p < 0.00001); however, more patients had side effects while taking PDE5Is and SSRIs (p < 0.00001; p < 0.00001). The efficacy of the combined treatment was significantly better than that of PDE5Is or SSRIs alone (p < 0.00001; p < 0.00001); however, more patients had side effects from the combined treatment than from SSRIs (p = 0.0002), with no significant difference in PDE5Is (p = 0.5). The efficacy of PDE5Is was better than that of SSRIs (p = 0.006), and no significant difference was observed in the frequency of side effects (p = 0.93).

conclusionsPDE5Is were significantly more effective than placebo or SSRIs for treating PE, while SSRIs were better than placebo. The combined treatment had better efficacy than PDE5Is or SSRIs alone.

Indexed as

HumansMalePhosphodiesterase 5 InhibitorsPremature EjaculationSelective Serotonin Reuptake InhibitorsTreatment OutcomePhosphodiesterase 5 InhibitorsSelective Serotonin Reuptake InhibitorsIntra-vaginal ejaculation latency timePhosphodiesterase-5 inhibitorPremature ejaculationRandomized controlled trialSelective serotonin reuptake inhibitors

Identifiers

PMID28913588
OpenAlexW2755700086

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.