ReviewCurrent opinion in genetics & development2017
Genetic backgrounds and hidden trait complexity in natural populations.
Review in Current opinion in genetics & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Predictive models of the genetic bases underlying budding yeast fitness in multiple environments.NAR genomics and bioinformatics · 2026Article
- Article
- Predictive models of the genetic bases underlying budding yeast fitness in multiple environments.bioRxiv : the preprint server for biology · 2025Article
- Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Species-wide survey of the expressivity and complexity spectrum of traits in yeast.PLoS genetics · 2024Article
- Gene expression variation underlying tissue-specific responses to copper stress inbioRxiv : the preprint server for biology · 2023Article
- Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects.Genome biology · 2023Article
- Perspective on the origin, resistance, and spread of the emerging human fungal pathogen Candida auris.PLoS pathogens · 2023Article
- Loss-of-function mutation survey revealed that genes with background-dependent fitness are rare and functionally related in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Multiple Stochastic Parameters Influence Genome Dynamics in a Heterozygous Diploid Eukaryotic Model.Journal of fungi (Basel, Switzerland) · 2022Article
- Article
- Ploidy and recombination proficiency shape the evolutionary adaptation to constitutive DNA replication stress.PLoS genetics · 2021Article
- Decoding 'Unnecessary Complexity': A Law of Complexity and a Concept of Hidden Variation Behind "Missing Heritability" in Precision Medicine.Journal of molecular evolution · 2021Review
- Population-specific genetic background for the OPRM1 variant rs1799971 (118A>G): implications for genomic medicine and functional analysis.Molecular psychiatry · 2021Article
- Cryptic genetic variation in a heat shock protein modifies the outcome of a mutation affecting epidermal stem cell development in C. elegans.Nature communications · 2021Article
- Article
- Dissecting the eQTL Micro-Architecture inFrontiers in genetics · 2020Article
- Complex modifier landscape underlying genetic background effects.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A stochastic epigenetic Mendelian oligogenic disease model for type 1 diabetes.Journal of autoimmunity · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Dissecting the genetic basis of natural phenotypic variation is a major goal in biology. We know that most traits are strongly heritable. However, their genetic architecture is a long-standing question, which is unfortunately confounded by the lack of complete knowledge of the genetic components as well as their phenotypic effect in a specific genetic background. Many genetic variants are known to affect phenotypes but the same functional variant can have a different effect on the phenotype in different individuals of the same species. Understanding the impact of genetic background on the expressivity of a given phenotype is essential because this effect complicates our ability to predict phenotype from genotype. Here, we briefly review recent progress on the exploration of the effect of genetic background and we discuss how a deeper characterization of the inheritance, expressivity and genetic interactions hidden behind the phenotypic landscape of natural variation could provide a better understanding of the relationship between genotype and phenotype.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.