Evidence map›Paper›PMID 28917313›Full record

ArticleVeterinary parasitology2017

Field evaluation of poultry red mite (Dermanyssus gallinae) native and recombinant prototype vaccines.

Kathryn Bartley, Frank Turnbull, Harry W Wright, John F Huntley, Javier Palarea-Albaladejo, Mintu Nath, Alasdair J Nisbet

Open access · hybridAbstract read
In one paragraph

Article in Veterinary parasitology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 51 citations in OpenAlex.

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  18. Metazoan Parasite Vaccines: Present Status and Future Prospects.Frontiers in cellular and infection microbiology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kathryn BartleyMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, United Kingdom. Electronic address: kathryn.bartley@moredun.ac.uk.
Frank TurnbullMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, United Kingdom.
Harry W WrightMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, United Kingdom.
John F HuntleyMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, United Kingdom.
Javier Palarea-AlbaladejoBiomathematics and Statistics Scotland, The King's Buildings, Peter Guthrie Tait Road, Edinburgh, EH9 3FD, United Kingdom.
Mintu NathBiomathematics and Statistics Scotland, The King's Buildings, Peter Guthrie Tait Road, Edinburgh, EH9 3FD, United Kingdom.
Alasdair J NisbetMoredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, Midlothian EH26 0PZ, United Kingdom.
Moredun Research Institute · GBBiomathematics and Statistics Scotland · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination is a desirable emerging strategy to combat poultry red mite (PRM), Dermanyssus gallinae. We performed trials, in laying hens in a commercial-style cage facility, to test the vaccine efficacy of a native preparation of soluble mite extract (SME) and of a recombinant antigen cocktail vaccine containing bacterially-expressed versions of the immunogenic SME proteins Deg-SRP-1, Deg-VIT-1 and Deg-PUF-1. Hens (n=384 per group) were injected with either vaccine or adjuvant only (control group) at 12 and 17 weeks of age and then challenged with PRM 10days later. PRM counts were monitored and, at the termination of the challenge period (17 weeks post challenge), average PRM counts in cages containing birds vaccinated with SME were reduced by 78% (p<0.001), compared with those in the adjuvant-only control group. When the trial was repeated using the recombinant antigen cocktail vaccine, no statistically significant differences in mean PRM numbers were observed in cages containing vaccinated or adjuvant-only immunised birds. The roles of antigen-specific antibody levels and duration in providing vaccine-induced and exposure-related protective immunity are discussed.

Indexed as

AnimalsAntigensArthropod ProteinsChickensMite InfestationsMitesPoultry DiseasesRecombinant ProteinsVaccinationVaccines, SyntheticAntigensArthropod ProteinsRecombinant ProteinsVaccines, SyntheticDermanyssus gallinaeField trialPoultry red miteSerpinSoluble mite extract (SME)VaccineVitellogenin

Identifiers

PMID28917313
PMCPMC5613835
OpenAlexW2725724938

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.