ReviewAutonomic neuroscience : basic & clinical2017
Homeostatic systems, biocybernetics, and autonomic neuroscience.
Review in Autonomic neuroscience : basic & clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Salivary lactoferrin as biomarker for Alzheimer's disease: Brain-immunity interactions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Pooled it
- Catecholamine metabolism revisited: from neurochemistry to integrative physiology and pathophysiology.Physiological reviews · 2026Review
- Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- From thought to action: The organization of spinal projecting neurons.Cell reports · 2025Review
- Revisiting Concepts of Thermal Physiology: Understanding Feedback and Feedforward Control, and Local Temperature Regulation.Acta physiologica (Oxford, England) · 2025Review
- Awake Bruxism Identification: A Specialized Assessment Tool for Children and Adolescents-A Pilot Study.International journal of environmental research and public health · 2025Article
- Stress tests and biomarkers of resilience: Proceedings of the second state of resilience science conference.Journal of the American Geriatrics Society · 2025Article
- Experimental Study on Emergency Psychophysiological and Behavioral Reactions to Coal Mining Accidents.Applied psychophysiology and biofeedback · 2024Article
- Novel Insights into Changes in Gene Expression within the Hypothalamus in Two Asthma Mouse Models: A Transcriptomic Lung-Brain Axis Study.International journal of molecular sciences · 2024Article
- The contribution of granger causality analysis to our understanding of cardiovascular homeostasis: from cardiovascular and respiratory interactions to central autonomic network control.Frontiers in network physiology · 2024Review
- Energy homeostasis from Lavoisier to control theory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Unique Features of the Immune Response in BTBR Mice.International journal of molecular sciences · 2022Article
- Homeostatic medicine: a strategy for exploring health and disease.Current medicine (Cham, Switzerland) · 2022Review
- Principles of Endocrine Regulation: Reconciling Tensions Between Robustness in Performance and Adaptation to Change.Frontiers in endocrinology · 2022Article
- Stress and the "extended" autonomic system.Autonomic neuroscience : basic & clinical · 2021Review
- Review
- Psychomotor Predictive Processing.Entropy (Basel, Switzerland) · 2021Article
- Multiscale Free Energy Analysis of Human Ecosystem Engineering.Entropy (Basel, Switzerland) · 2021Article
- Decreased salivary lactoferrin levels are specific to Alzheimer's disease.EBioMedicine · 2020Article
- The control mechanisms of heart rate dynamics in a new heart rate nonlinear time series model.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this review we describe a series of major concepts introduced during the past 150years that have contributed to our current understanding about how physiological processes required for well-being and survival are regulated. One can theorize that hierarchical networks involving input-output relationships continuously orchestrate and learn adaptive patterns of observable behaviors, cognition, memory, mood, and autonomic systems. Taken together, these networks function as "good regulators" determining levels of internal variables and act as if there were homeostatic comparators ("homeostats"). The consequences of models with vs. without homeostats remain the same in terms of allostatic load and the eventual switch from stabilizing negative feedback loops to destabilizing, pathogenic positive feedback loops. Understanding this switch seems important for comprehending senescence-related, neurodegenerative disorders that involve the autonomic nervous system. Our general proposal is that disintegration of homeostatic systems causes disorders of regulation in degenerative diseases and that medical cybernetics can inspire and rationalize new approaches to treatment and prevention.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.