Evidence map›Paper›PMID 28922364›Full record

Trial reportPloS one2017

Association of epicardial adipose tissue with serum level of cystatin C in type 2 diabetes.

Tomomi Murai, Noriko Takebe, Kan Nagasawa, Yusuke Todate, Riyuki Nakagawa, Rieko Nakano, Mari Hangai, Yutaka Hasegawa, Yoshihiko Takahashi, Kunihiro Yoshioka and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Tomomi MuraiDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Noriko TakebeDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Kan NagasawaDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Yusuke TodateDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Riyuki NakagawaDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Rieko NakanoDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Mari HangaiDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Yutaka HasegawaDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Yoshihiko TakahashiDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Kunihiro YoshiokaDivision of Cardiovascular Radiology, Department of Radiology, Iwate Medical University, Morioka, Japan.
Yasushi IshigakiDivision of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.ORCID http://orcid.org/0000-0003-2479-5752
Iwate Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAccumulation of epicardial adipose tissue (EAT) is considered to be a cardiovascular risk factor independent from visceral adiposity, obesity, hypertension and diabetes. We explored the parameters related to EAT accumulation, aiming to clarify the novel pathophysiological roles of EAT in subjects with type 2 diabetes (T2DM).

methodsWe examined the laboratory values, including cystatinC, and surrogate markers used for evaluating atherosclerosis. EAT was measured as the sum of the adipose tissue area, obtained by plain computed tomography scans in 208 subjects with T2DM but no history of coronary artery disease.

resultsEAT correlated positively with age, body mass index (BMI), visceral fat area, leptin, cystatin C and C-peptide, while correlating negatively with adiponectin, estimated glomerular filteration rate (eGFR) and the liver-to-spleen ratio. Multiple linear regression analysis revealed serum cystatin C (β = 0.175), leptin (β = 0.536), BMI (β = 0.393) and age (β = 0.269) to be the only parameters showing independent statistically significant associations with EAT. When cystatin C was replaced with eGFR, eGFR showed no significant correlation with EAT. In reverse analysis, serum cystatin C was significantly associated with EAT after adjustment in multivariate analysis. DISCUSSION: EAT accumulation and elevated cystatin C have been independently regarded as risk factors influencing atherosclerosis. The strong association between EAT and cystatin C demonstrated herein indicates that EAT accumulation may play an important role in Cystatin C secretion, possibly contributing to cardiometabolic risk in T2DM patients.

Indexed as

Adipose TissueAdultAgedBiomarkersCoronary Artery DiseaseCystatin CDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedPericardiumTomography, X-Ray ComputedBiomarkersCST3 protein, humanCystatin C

Identifiers

PMID28922364
PMCPMC5603154
OpenAlexW2755410914

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.