Evidence map›Paper›PMID 28923914›Full record

ReviewJournal of the American Society of Nephrology : JASN2017

New Ultrasound Techniques Promise Further Advances in AKI and CKD.

Travis D Hull, Anupam Agarwal, Kenneth Hoyt

Abstract readReview
In one paragraph

Review in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. New approaches to acute kidney injury.Clinical kidney journal · 2024
    Article
  8. Renal Ultrasonography in Children: Principles and Emerging Techniques.Current treatment options in pediatrics · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Evaluation of Nonlinear Contrast Pulse Sequencing for Use in Super-Resolution Ultrasound Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Travis D HullDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Anupam AgarwalDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Kenneth HoytDepartment of Bioengineering, University of Texas at Dallas, Richardson, Texas; and kenneth.hoyt@utdallas.edu.

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
Human Heme Oxygenase-1 Gene Regulation in Renal InjuryR01DK059600 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ANUPAM, GEORGE, JAMES F · 2002 to 2019
$4.5M
Molecular Ultrasound Imaging of Cancer Response to Antiangiogenic TherapyK25EB017222 · NIBIB · UNIVERSITY OF TEXAS DALLAS · PI HOYT, KENNETH · 2014 to 2018
$804k
Noninvasive Pressure Estimation in Breast Cancer using UltrasoundR21CA212851 · NCI · UNIVERSITY OF TEXAS DALLAS · PI HOYT, KENNETH · 2017 to 2018
$366k
NCI NIH HHS R21 CA212851NIBIB NIH HHS K25 EB017222NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK059600
6 · The paper itself

Abstract

AKI and CKD are important clinical problems because they affect many patients and the associated diagnostic and treatment paradigms are imperfect. Ultrasound is a cost-effective, noninvasive, and simple imaging modality that offers a multitude of means to improve the diagnosis, monitoring, and treatment of both AKI and CKD, especially considering recent advances in this technique. Ultrasound alone can attenuate AKI and prevent CKD by stimulating the splenic cholinergic anti-inflammatory pathway. Additionally, microbubble contrast agents are improving the sensitivity and specificity of ultrasound for diagnosing kidney disease, especially when these agents are conjugated to ligand-specific mAbs or peptides, which make the dynamic assessment of disease progression and response to treatment possible. More recently, drug-loaded microbubbles have been developed and the load release by ultrasound exposure has been shown to be a highly specific treatment modality, making the potential applications of ultrasound even more promising. This review focuses on the multiple strategies for using ultrasound with and without microbubble technology for enhancing our understanding of the pathophysiology of AKI and CKD.

Indexed as

Acute Kidney InjuryAnimalsAntibodies, MonoclonalAnti-Inflammatory AgentsContrast MediaCritical IllnessDisease ProgressionHospitalizationHumansInflammationKidneyMicrobubblesPeptidesRatsRenal Insufficiency, ChronicUltrasonographyAntibodies, MonoclonalAnti-Inflammatory AgentsContrast MediaPeptidesacute kidney injurychronic kidney diseaseultrasound

Identifiers

PMID28923914
PMCPMC5698079

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.