Evidence map›Paper›PMID 28923975›Full record

ArticleThe Journal of cell biology2017

Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature.

Frederic Daste, Astrid Walrant, Mikkel R Holst, Jonathan R Gadsby, Julia Mason, Ji-Eun Lee, Daniel Brook, Marcel Mettlen, Elin Larsson, Steven F Lee and 2 more

Open access · hybridAbstract readVideo-Audio Media
In one paragraph

Article in The Journal of cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 95 citations in OpenAlex.

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  17. Embedding of HIV Egress within Cortical F-Actin.Pathogens (Basel, Switzerland) · 2022
    Article
  18. Article
  19. Article
  20. PI(3,4)PProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Frederic DasteWellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, England, UK.
Astrid WalrantWellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, England, UK.
Mikkel R HolstIntegrative Medical Biology, Umeå University, Umeå, Sweden.ORCID 0000-0002-5538-4406
Jonathan R GadsbyWellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, England, UK.ORCID 0000-0001-7986-4917
Julia MasonWellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, England, UK.
Ji-Eun LeeDepartment of Chemistry, University of Cambridge, Cambridge, England, UK.
Daniel BrookWellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, England, UK.
Marcel MettlenUniversity of Texas Southwestern Medical Center, Dallas, TX.
Elin LarssonIntegrative Medical Biology, Umeå University, Umeå, Sweden.
Steven F LeeDepartment of Chemistry, University of Cambridge, Cambridge, England, UK.
Richard LundmarkIntegrative Medical Biology, Umeå University, Umeå, Sweden.
Jennifer L GallopWellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge, England, UK j.gallop@gurdon.cam.ac.uk.ORCID 0000-0002-9978-1382
University of Cambridge · GBUmeå University · SEThe University of Texas Southwestern Medical Center · US

Funding

Cancer Research UK A14492Wellcome Trust 092096
6 · The paper itself

Abstract

The conditional use of actin during clathrin-mediated endocytosis in mammalian cells suggests that the cell controls whether and how actin is used. Using a combination of biochemical reconstitution and mammalian cell culture, we elucidate a mechanism by which the coincidence of PI(4,5)P

Indexed as

EndocytosisActin-Related Protein 2-3 ComplexActinsAnimalscdc42 GTP-Binding ProteinClathrinClathrin-Coated VesiclesCoated Pits, Cell-MembraneCRISPR-Cas SystemsCytoskeletal ProteinsHeLa CellsHumansHydrolysisIntracellular Signaling Peptides and ProteinsOculocerebrorenal SyndromePhosphatidylinositol 4,5-DiphosphateActin-Related Protein 2-3 ComplexActinscdc42 GTP-Binding ProteinClathrinCytoskeletal ProteinsIntracellular Signaling Peptides and Proteinsphosphatidylinositol-3,4-bisphosphate 4-phosphatasephosphatidylinositol 3-phosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol PhosphatesPhosphatidylinositolsphosphoinositide-3,4-bisphosphatePhosphoric Monoester HydrolasesSNX9 protein, humanSorting NexinsWASL protein, humanWIPF1 protein, humanWiskott-Aldrich Syndrome Protein, Neuronal

Identifiers

PMID28923975
PMCPMC5674896
OpenAlexW2755338116

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.