Evidence map›Paper›PMID 28927945›Full record

SynthesisJournal of the American Medical Directors Association2017

Consensus Approaches to Identify Incident Dementia in Cohort Studies: Systematic Review and Approach in the Successful Aging after Elective Surgery Study.

Eyal Y Kimchi, Tammy T Hshieh, Ray Guo, Bonnie Wong, Margaret O'Connor, Edward R Marcantonio, Eran D Metzger, Jason Strauss, Steven E Arnold, Sharon K Inouye and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Medical Directors Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A Multimodal Approach for Study Diagnosis of MCI and Dementia in the Successful Aging After Elective Surgery (SAGES) Cohort.The American journal of geriatric psychiatry. Open science, education, and practice · 2026
    Article
  4. Article
  5. Postoperative cognitive dysfunction: a concept analysis.Aging clinical and experimental research · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Eyal Y KimchiDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Tammy T HshiehDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Ray GuoAging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA.
Bonnie WongDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Margaret O'ConnorDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Edward R MarcantonioDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Eran D MetzgerDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Jason StraussDepartment of Psychiatry, Cambridge Health Alliance, Cambridge, MA; Harvard Medical School, Boston, MA.
Steven E ArnoldDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Sharon K InouyeAging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Tamara G FongAging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address: tfong@bidmc.harvard.edu.
Harvard University · USBeth Israel Deaconess Medical Center · USCambridge Health Alliance · USHebrew SeniorLife · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2010 to 2022
$26.7M
Development and Validation of a Delirium Severity ToolkitR01AG044518 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K., JONES, RICHARD N · 2014 to 2024
$7.3M
Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
Training in Neurostatistics and NeuroepidemiologyT32NS048005 · NINDS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ONNELA, JUKKA-PEKKA · 2004 to 2018
$3.2M
Mid-Career Mentoring Award for Patient-Oriented Research in AgingK24AG035075 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARCANTONIO, EDWARD R · 2010 to 2021
$1.9M
K07 Leadership GrantK07AG041835 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2013 to 2017
$656k
Determining the pathophysiology of delirium in the elderly through translational modelsR03AG050878 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI KIMCHI, EYAL YAACOV · 2015 to 2016
$261k
NCATS NIH HHS UL1 TR001102NIA NIH HHS K07 AG041835NIA NIH HHS K24 AG035075NIA NIH HHS P01 AG031720NIA NIH HHS R01 AG044518NIA NIH HHS R03 AG050878NIA NIH HHS R24 AG054259NINDS NIH HHS T32 NS048005
6 · The paper itself

Abstract

objectivesTo survey the current methods used to ascertain dementia and mild cognitive impairment (MCI) in longitudinal cohort studies, to categorize differences in approaches and to identify key components of expert panel methodology in current use.

methodsWe searched PubMed for the past 10 years, from March 6, 2007 to March 6, 2017 using a combination of controlled vocabulary and keyword terms to identify expert panel consensus methods used to diagnose MCI or dementia in large cohort studies written in English. From these results, we identified a framework for reporting standards and describe as an exemplar the clinical consensus procedure used in an ongoing study of elective surgery patients (the Successful Aging after Elective Surgery study).

resultsThirty-one articles representing unique cohorts were included. Among published methods, membership of experts panel varied significantly. There was more similarity in what types of information was use to ascertain disease status. However, information describing the diagnostic decision process and resolution of disagreements was often lacking.

conclusionsMethods used for expert panel diagnosis of MCI and dementia in large cohort studies are widely variable, and there is a need for more standardized reporting of these approaches. By describing the procedure in which our expert panel achieved consensus diagnoses, we hope to encourage the development and publication of well-founded and reproducible methods for diagnosis of MCI and dementia in longitudinal studies.

Indexed as

AgingAlzheimer DiseaseCognitive DysfunctionElective Surgical ProceduresAgedAged, 80 and overAge FactorsConsensusConsensus Statements as TopicDisease ProgressionFemaleGeriatric AssessmentHumansIncidenceLongitudinal StudiesMaleConsensusdementiadiagnosismild cognitive impairment

Identifiers

PMID28927945
PMCPMC5701828
OpenAlexW2754527275

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.