Evidence map›Paper›PMID 28928121›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes.

Elizabeth A Rondini, Ljiljana Mladenovic-Lucas, William R Roush, Geoff T Halvorsen, Alex E Green, James G Granneman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  10. Molecular Modeling of ABHD5 Structure and Ligand Recognition.Frontiers in molecular biosciences · 2022
    Article
  11. Review
  12. Article
  13. Review
  14. Optogenetic-induced sympathetic neuromodulation of brown adipose tissue thermogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Elizabeth A RondiniCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan (E.A.R., L.M.-L., J.G.G.); Department of Chemistry, Scripps Research Institute, Jupiter, Florida (W.R.R., G.T.H.); and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (A.E.G.).
Ljiljana Mladenovic-LucasCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan (E.A.R., L.M.-L., J.G.G.); Department of Chemistry, Scripps Research Institute, Jupiter, Florida (W.R.R., G.T.H.); and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (A.E.G.).
William R RoushCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan (E.A.R., L.M.-L., J.G.G.); Department of Chemistry, Scripps Research Institute, Jupiter, Florida (W.R.R., G.T.H.); and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (A.E.G.).
Geoff T HalvorsenCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan (E.A.R., L.M.-L., J.G.G.); Department of Chemistry, Scripps Research Institute, Jupiter, Florida (W.R.R., G.T.H.); and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (A.E.G.).
Alex E GreenCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan (E.A.R., L.M.-L., J.G.G.); Department of Chemistry, Scripps Research Institute, Jupiter, Florida (W.R.R., G.T.H.); and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (A.E.G.).
James G GrannemanCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan (E.A.R., L.M.-L., J.G.G.); Department of Chemistry, Scripps Research Institute, Jupiter, Florida (W.R.R., G.T.H.); and Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada (A.E.G.) jgranne@med.wayne.edu.
McMaster University · CAScripps Research Institute · USWayne State University · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Analysis of Lipolytic Trafficking in Adipocytes.R01DK076629 · NIDDK · WAYNE STATE UNIVERSITY · PI James G Granneman, Christopher V Kelly · 2009 to 2026
$7.1M
Preclinical validation of ABHD5 as a target for treatment of obesity.R01DK105963 · NIDDK · WAYNE STATE UNIVERSITY · PI GRANNEMAN, JAMES G · 2015 to 2018
$2.7M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK076629NIDDK NIH HHS R01 DK105963
6 · The paper itself

Abstract

Current knowledge regarding acute regulation of adipocyte lipolysis is largely based on receptor-mediated activation or inhibition of pathways that influence intracellular levels of cAMP, thereby affecting protein kinase A (PKA) activity. We recently identified synthetic ligands of

Indexed as

1-Acylglycerol-3-Phosphate O-AcyltransferaseAdipocytes, BrownAdipocytes, WhiteAnimalsCell LineCyclic AMP-Dependent Protein KinasesEnzyme ActivationFemaleHydrolysisInsulinLigandsLipolysisMicePerilipin-1PhosphorylationPiperazines1-Acylglycerol-3-Phosphate O-AcyltransferaseAbhd5 protein, mouseCyclic AMP-Dependent Protein KinasesInsulinLigandsPerilipin-1PiperazinesReceptors, Adrenergic, betaSterol EsteraseThiazepinesTriglyceridesUrea

Identifiers

PMID28928121
PMCPMC5698943
OpenAlexW2755241910

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.