Evidence map›Paper›PMID 28932813›Full record

ArticlemSphere

14-3-3 Regulates Actin Filament Formation in the Deep-Branching Eukaryote

Jana Krtková, Jennifer Xu, Marco Lalle, Melissa Steele-Ogus, Germain C M Alas, David Sept, Alexander R Paredez

Open access · goldAbstract read
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. Omics Analyses ofGenes · 2022
    Article
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  6. Review
  7. Staging Encystation Progression inFrontiers in cell and developmental biology · 2021
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Jana KrtkováDepartment of Biology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-9197-9730
Jennifer XuDepartment of Biology, University of Washington, Seattle, Washington, USA.
Marco LalleDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.ORCID 0000-0001-5168-2150
Melissa Steele-OgusDepartment of Biology, University of Washington, Seattle, Washington, USA.
Germain C M AlasDepartment of Biology, University of Washington, Seattle, Washington, USA.
David SeptDepartment of Biomedical Engineering and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-3719-2483
Alexander R ParedezDepartment of Biology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-9298-3264
University of Washington · USIstituto Superiore di Sanità · ITUniversity of Michigan · US

Funding

Rac: a critical regulator of the cytoskeleton and membrane trafficking in GiardiaR01AI110708 · NIAID · UNIVERSITY OF WASHINGTON · PI PAREDEZ, ALEXANDER RICHARD · 2015 to 2019
$1.9M
NIAID NIH HHS R01 AI110708
6 · The paper itself

Abstract

The phosphoserine/phosphothreonine-binding protein 14-3-3 is known to regulate actin; this function has been previously attributed to sequestration of phosphorylated cofilin. 14-3-3 was identified as an actin-associated protein in the deep-branching eukaryote

Indexed as

14-3-3actinevolutionary cell biologyRho GTPase

Identifiers

PMID28932813
PMCPMC5597967
OpenAlexW2754717626

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.