Evidence map›Paper›PMID 28935823›Full record

Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2018

Brachial artery vasodilatory response and wall shear rate determined by multigate Doppler in a healthy young cohort.

Kunihiko Aizawa, Sara Sbragi, Alessandro Ramalli, Piero Tortoli, Francesco Casanova, Carmela Morizzo, Clare E Thorn, Angela C Shore, Phillip E Gates, Carlo Palombo

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Interaction of macro- and microvascular function underlies brachial artery flow-mediated dilation in humans.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Kunihiko AizawaDiabetes and Vascular Medicine Research Centre, National Institute of Health Research Exeter Clinical Research Facility, University of Exeter Medical School , Exeter , United Kingdom.ORCID 0000-0002-0025-2115
Sara SbragiDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa , Pisa , Italy.
Alessandro RamalliDepartment of Information Engineering, University of Florence , Florence , Italy.
Piero TortoliDepartment of Information Engineering, University of Florence , Florence , Italy.
Francesco CasanovaDiabetes and Vascular Medicine Research Centre, National Institute of Health Research Exeter Clinical Research Facility, University of Exeter Medical School , Exeter , United Kingdom.
Carmela MorizzoDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa , Pisa , Italy.
Clare E ThornDiabetes and Vascular Medicine Research Centre, National Institute of Health Research Exeter Clinical Research Facility, University of Exeter Medical School , Exeter , United Kingdom.
Angela C ShoreDiabetes and Vascular Medicine Research Centre, National Institute of Health Research Exeter Clinical Research Facility, University of Exeter Medical School , Exeter , United Kingdom.
Phillip E GatesDiabetes and Vascular Medicine Research Centre, National Institute of Health Research Exeter Clinical Research Facility, University of Exeter Medical School , Exeter , United Kingdom.
Carlo PalomboDepartment of Surgical, Medical, Molecular Pathology and Critical Care Medicine, University of Pisa , Pisa , Italy.
University of Exeter · GBUniversity of Pisa · ITUniversity of Florence · IT

Funding

Department of Health
6 · The paper itself

Abstract

Wall shear rate (WSR) is an important stimulus for the brachial artery flow-mediated dilation (FMD) response. However, WSR estimation near the arterial wall by conventional Doppler is inherently difficult. To overcome this limitation, we utilized multigate Doppler to accurately determine the WSR stimulus near the vessel wall simultaneously with the FMD response using an integrated FMD system [Ultrasound Advanced Open Platform (ULA-OP)]. Using the system, we aimed to perform a detailed analysis of WSR-FMD response and establish novel WSR parameters in a healthy young population. Data from 33 young healthy individuals (27.5 ± 4.9 yr, 19 females) were analyzed. FMD was assessed with reactive hyperemia using ULA-OP. All acquired raw data were postprocessed using custom-designed software to obtain WSR and diameter parameters. The acquired velocity data revealed that nonparabolic flow profiles within the cardiac cycle and under different flow states, with heterogeneity between participants. We also identified seven WSR magnitude and four WSR time-course parameters. Among them, WSR area under the curve until its return to baseline was the strongest predictor of the absolute ( R

Indexed as

VasodilationAdultBrachial ArteryCohort StudiesFemaleHumansMaleUltrasonography, DopplerYoung Adultendothelial functionreactive hyperemiaultrasoundvasodilationwall shear stress

Identifiers

PMID28935823
PMCPMC5866444
OpenAlexW2757450321

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.