ArticleDiabetologia2018
Acute renal metabolic effect of metformin assessed with hyperpolarised MRI in rats.
Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Glycolytic alterations as biomarkers in polycystic kidney disease: A study using a PKD1 knockout model in NRK-52E rat kidney epithelial cells.Physiological reports · 2026Article
- Metformin Restrains the Proliferation of CD4+ T Lymphocytes by Inducing Cell Cycle Arrest in Normo- and Hyperglycemic Conditions.Biomolecules · 2024Article
- HyperpolarizedMagnetic resonance in medicine · 2022Article
- Metabolic Action of Metformin.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Imaging in experimental models of diabetes.Acta diabetologica · 2022Review
- Offset of apparent hyperpolarizedNMR in biomedicine · 2021Article
- Is metformin associated with acute kidney injury? A case-control study of patients with type 2 diabetes admitted with acute infection.Journal of nephrology · 2021Article
- In Vivo Assessment of Metabolic Abnormality in Alport Syndrome Using Hyperpolarized [1-Metabolites · 2021Article
- Cellular and Molecular Mechanisms of Metformin Action.Endocrine reviews · 2021Review
- Hyperpolarized Carbon (Methods in molecular biology (Clifton, N.J.) · 2021Article
- Hyperpolarized Carbon (Methods in molecular biology (Clifton, N.J.) · 2021Article
- Organ-specific metabolic profiles of the liver and kidney during brain death and afterwards during normothermic machine perfusion of the kidney.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model.BMJ open diabetes research & care · 2020Article
- The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective.International journal of molecular sciences · 2020Review
- Sex Differences in Kidney Function and Metabolism Assessed Using Hyperpolarized [1-Tomography (Ann Arbor, Mich.) · 2020Article
- HyperpolarisedMagma (New York, N.Y.) · 2020Review
- High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes.Tomography (Ann Arbor, Mich.) · 2019Article
- Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.The Journal of biological chemistry · 2019Article
- Hyperpolarized [1-Physiological reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisMetformin inhibits hepatic mitochondrial glycerol phosphate dehydrogenase, thereby increasing cytosolic lactate and suppressing gluconeogenesis flux in the liver. This inhibition alters cytosolic and mitochondrial reduction-oxidation (redox) potential, which has been reported to protect organ function in several disease states including diabetes. In this study, we investigated the acute metabolic and functional changes induced by metformin in the kidneys of both healthy and insulinopenic Wistar rats used as a model of diabetes.
methodsDiabetes was induced by intravenous injection of streptozotocin, and kidney metabolism in healthy and diabetic animals was investigated 4 weeks thereafter using hyperpolarised
resultsMetformin increased renal blood flow, but did not change total kidney oxygen consumption. In healthy rat kidneys, metformin increased [1- CONCLUSIONS/
interpretationThis study demonstrates that metformin-induced acute metabolic alterations in healthy kidneys favoured anaerobic metabolism at the expense of aerobic metabolism. The results suggest that metformin directly alters the renal redox state, with elevated renal cytosolic redox states as well as decreased mitochondrial redox state. These findings suggest redox biology as a novel target to eliminate the renal complications associated with metformin treatment in individuals with impaired renal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.