Evidence map›Paper›PMID 28939422›Full record

ArticleFree radical biology & medicine2017

Suppressed ubiquitination of Nrf2 by p47

Kyun Ha Kim, Ruxana T Sadikot, Ji Yeon Lee, Han-Sol Jeong, Yu-Kyoung Oh, Timothy S Blackwell, Myungsoo Joo

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Neuroprotection of Truncated Peptide IIAVE fromMolecules (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Article
  8. A dual Keap1 and p47Cell death & disease · 2022
    Article
  9. Nutrients · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The Antidiabetic and Antinephritic Activities ofOxidative medicine and cellular longevity · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kyun Ha KimDivision of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Ruxana T SadikotSection of Pulmonary and Critical Care Medicine, Atlanta Veterans Affairs Medical Center, Emory University, Decatur, GA 30033, USA.
Ji Yeon LeeDivision of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Han-Sol JeongDivision of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Yu-Kyoung OhCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
Timothy S BlackwellDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Myungsoo JooDivision of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea. Electronic address: mjoo@pusan.ac.kr.
Pusan National University · KREmory University · USSeoul National University · KRVanderbilt University · US

Funding

Mechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLACKWELL, TIMOTHY S. · 2010 to 2020
$21.6M
NHLBI NIH HHS P01 HL092870
6 · The paper itself

Abstract

Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti-oxidant enzymes that nullifies ROS, ROS activating Nrf2 is a critical negative regulatory step for countering the deleterious effects of ROS. Here, we postulate whether, along with ROS activating Nrf2, NADPH oxidase components also participate in direct activation of Nrf2, contributing to protection from ROS. Our results show that the p47

Indexed as

UbiquitinationAnimalsDisease Models, AnimalHEK293 CellsHumansKelch-Like ECH-Associated Protein 1LipopolysaccharidesMiceNADPH OxidasesNF-E2-Related Factor 2PneumoniaRAW 264.7 CellsReactive Oxygen SpeciesSignal TransductionKelch-Like ECH-Associated Protein 1LipopolysaccharidesNADPH Oxidasesneutrophil cytosolic factor 1NF-E2-Related Factor 2Reactive Oxygen SpeciesKeap1Lung inflammationNADPH oxidaseNrf2p47phoxUbiquitination

Identifiers

PMID28939422
PMCPMC5889093
OpenAlexW2756319332

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.