Trial reportActa psychiatrica Scandinavica2017
Increased thalamic resting-state connectivity as a core driver of LSD-induced hallucinations.
Trial report in Acta psychiatrica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- What fMRI studies say about the nature of the psychedelic effect: a scoping review.Frontiers in neuroscience · 2025Pooled it
- Dose-response relationships of LSD-induced subjective experiences in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Pooled it
- Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine.Molecular psychiatry · 2025Trial
- The effect of lysergic acid diethylamide (LSD) on whole-brain functional and effective connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Low doses of lysergic acid diethylamide (LSD) increase reward-related brain activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Trial
- MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Trial
- Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers.Biological psychiatry · 2019Trial
- Effective connectivity changes in LSD-induced altered states of consciousness in humans.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Altered network hub connectivity after acute LSD administration.NeuroImage. Clinical · 2018Trial
- Increased thalamic resting-state connectivity as a core driver of LSD-induced hallucinations.Acta psychiatrica Scandinavica · 2017Trial
- LSD reconfigures cortical dynamics through faster brain rhythms and increased fractal dimension.Communications biology · 2026Article
- Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes.Neuroscience and biobehavioral reviews · 2026Review
- The intersection between psychedelics and schizophrenia spectrum disorders: Reevaluating risk and therapeutic potential.Journal of psychopharmacology (Oxford, England) · 2026Review
- Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects.Current topics in behavioral neurosciences · 2026Review
- The neurobiology of altered states of consciousness induced by drumming and other rhythmic sound patterns.Annals of the New York Academy of Sciences · 2025Review
- The compulsive eating paradigm: can psychedelics help in treating obesity?Journal of eating disorders · 2025Review
- The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State.Human brain mapping · 2025Article
- Uncovering Psychedelics: From Neural Circuits to Therapeutic Applications.Pharmaceuticals (Basel, Switzerland) · 2025Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIt has been proposed that the thalamocortical system is an important site of action of hallucinogenic drugs and an essential component of the neural correlates of consciousness. Hallucinogenic drugs such as LSD can be used to induce profoundly altered states of consciousness, and it is thus of interest to test the effects of these drugs on this system.
method100 μg LSD was administrated orally to 20 healthy participants prior to fMRI assessment. Whole brain thalamic functional connectivity was measured using ROI-to-ROI and ROI-to-voxel approaches. Correlation analyses were used to explore relationships between thalamic connectivity to regions involved in auditory and visual hallucinations and subjective ratings on auditory and visual drug effects.
resultsLSD caused significant alterations in all dimensions of the 5D-ASC scale and significantly increased thalamic functional connectivity to various cortical regions. Furthermore, LSD-induced functional connectivity measures between the thalamus and the right fusiform gyrus and insula correlated significantly with subjective auditory and visual drug effects.
conclusionHallucinogenic drug effects might be provoked by facilitations of cortical excitability via thalamocortical interactions. Our findings have implications for the understanding of the mechanism of action of hallucinogenic drugs and provide further insight into the role of the 5-HT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.