ArticleToxicology and applied pharmacology2017
Inhalation exposure to three-dimensional printer emissions stimulates acute hypertension and microvascular dysfunction.
Article in Toxicology and applied pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 83 citations in OpenAlex.
- Inhalation exposure to surrogate military burn pit emissions impairs systemic microvascular function: linking pulmonary insult and diverse peripheral responses.Particle and fibre toxicology · 2026Article
- Assessment of the carcinogenic potential of particulate matter and organic compound mixtures generated from 3D printing devices in Balb/c 3T3-1-1 cells.Scientific reports · 2026Article
- Neuroendocrine effects of inhaling emissions generated by 3-dimensional (3D)-printing with polycarbonate stock.Journal of toxicology and environmental health. Part A · 2026Article
- Reducing particulate emissions from 3D printers using low-cost enclosures and engineering controls.Rapid prototyping journal · 2025Article
- Review
- Exposure to emissions generated by 3-dimensional printing with polycarbonate: effects on peripheral vascular function, cardiac vascular morphology and expression of markers of oxidative stress in male rat cardiac tissue.Journal of toxicology and environmental health. Part A · 2024Article
- Single pulmonary nanopolystyrene exposure in late-stage pregnancy dysregulates maternal and fetal cardiovascular function.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Pulmonary evaluation of whole-body inhalation exposure of polycarbonate (PC) filament 3D printer emissions in rats.Journal of toxicology and environmental health. Part A · 2024Article
- Using particle dimensionality-based modeling to estimate lung carcinogenicity of 3D printer emissions.Journal of applied toxicology : JAT · 2024Article
- Investigating environmentally persistent free radicals (EPFRs) emissions of 3D printing process.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2024Article
- Article
- 3D printer emissions elicit filament-specific and dose-dependent metabolic and genotoxic effects in human airway epithelial cells.Frontiers in public health · 2024Article
- Inhalation of polycarbonate emissions generated during 3D printing processes affects neuroendocrine function in male rats.Journal of toxicology and environmental health. Part A · 2023Article
- Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats.Particle and fibre toxicology · 2023Article
- Metal compositions of particle emissions from material extrusion 3D printing: Emission sources and indoor exposure modeling.The Science of the total environment · 2023Article
- An explorative study on respiratory health among operators working in polymer additive manufacturing.Frontiers in public health · 2023Article
- Variability in the inorganic composition of colored acrylonitrile-butadiene-styrene and polylactic acid filaments used in 3D printing.SN applied sciences · 2022Article
- Identification of effective control technologies for additive manufacturing.Journal of toxicology and environmental health. Part B, Critical reviews · 2022Review
- Human exposure to metals in consumer-focused fused filament fabrication (FFF)/ 3D printing processes.The Science of the total environment · 2022Review
- Exploring Methods for Surveillance of Occupational Exposure from Additive Manufacturing in Four Different Industrial Facilities.Annals of work exposures and health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Fused deposition modeling (FDM™), or three-dimensional (3D) printing has become routine in industrial, occupational and domestic environments. We have recently reported that 3D printing emissions (3DPE) are complex mixtures, with a large ultrafine particulate matter component. Additionally, we and others have reported that inhalation of xenobiotic particles in this size range is associated with an array of cardiovascular dysfunctions. Sprague-Dawley rats were exposed to 3DPE aerosols via nose-only exposure for ~3h. Twenty-four hours later, intravital microscopy was performed to assess microvascular function in the spinotrapezius muscle. Endothelium-dependent and -independent arteriolar dilation were stimulated by local microiontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP). At the time of experiments, animals exposed to 3DPE inhalation presented with a mean arterial pressure of 125±4mmHg, and this was significantly higher than that for the sham-control group (94±3mmHg). Consistent with this pressor response in the 3DPE group, was an elevation of ~12% in resting arteriolar tone. Endothelium-dependent arteriolar dilation was significantly impaired after 3DPE inhalation across all iontophoretic ejection currents (0-27±15%, compared to sham-control: 15-120±21%). Endothelium-independent dilation was not affected by 3DPE inhalation. These alterations in peripheral microvascular resistance and reactivity are consistent with elevations in arterial pressure that follow 3DPE inhalation. Future studies must identify the specific toxicants generated by FDM™ that drive this acute pressor response.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.